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Zenazocine

From Wikipedia, the free encyclopedia
Opioid analgesic
Pharmaceutical compound
Zenazocine
Clinical data
ATC code
  • None
Legal status
Legal status
  • In general: non-regulated
Identifiers
  • 1-[(1S,9R)-4-hydroxy-1,10,13-trimethyl-10-azatricyclo[7.3.1.02,7]trideca-2,4,6-trien-13-yl]-6-methyl-3-heptanone
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC23H35NO2
Molar mass357.538 g·mol−1
3D model (JSmol)
  • O=C(CCC(C)C)CCC3([C@@H]2N(CC[C@]3(c1c(ccc(O)c1)C2)C)C)C
  • InChI=1S/C23H35NO2/c1-16(2)6-8-18(25)10-11-23(4)21-14-17-7-9-19(26)15-20(17)22(23,3)12-13-24(21)5/h7,9,15-16,21,26H,6,8,10-14H2,1-5H3/t21-,22+,23?/m1/s1
  • Key:JZFZEWWOIOYBTQ-AXWGZAFASA-N

Zenazocine (INN;WIN-42,964) is anopioidanalgesic of thebenzomorphan family which made it tophase IIclinical trials before development was ultimately halted and it was never marketed.[1][2] It acts as apartial agonist of theμ- andδ-opioid receptors, with lessintrinsic activity at the former receptor and more at the latter receptor (hence, it behaves moreantagonistically at the former and moreagonistically at the latter), and producesantinociceptive effects in animal studies.[1]

See also

[edit]

References

[edit]
  1. ^abWard SJ, Pierson AK, Michne WF (February 1985). "Pharmacological profiles of tonazocine (Win 42156) and zenazocine (Win 42964)".Neuropeptides.5 (4–6):375–8.doi:10.1016/0143-4179(85)90032-0.PMID 2860595.S2CID 20674308.
  2. ^Cotton R, James R (1985)."Chapter 3. Analgesics, Opioids and Opioid Receptors". In Bailey DM (ed.).Annual Reports in Medicinal Chemistry. Vol. 20. Academic Press. pp. 21–30.doi:10.1016/S0065-7743(08)61029-5.ISBN 978-0-12-040520-6.
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μ-opioid
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