Zinc finger E-box-binding homeobox 1 is aprotein that in humans is encoded by theZEB1gene.[5][6][7]
ZEB1 (previously known as TCF8) encodes azinc finger andhomeodomaintranscription factor that represses T-lymphocyte-specificIL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2transcription start site.[7][6] ZEB1 and its mammalian paralogZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has seven zinc fingers and one homeodomain.[8] The structure of the homeodomain is shown on the right.
Mutations of the gene are linked toposterior polymorphous corneal dystrophy 3. ZEB1 downregulatesE-cadherin and inducesepithelial to mesenchymal transition in breast and other carcinomas[9] A recent study suggested its contributing role inlung cancer invasiveness and metastasis development.[10] Overexpression of ZEB1 has been identified as a potential risk factor for recurrence and poor prognosis in several types of cancers.[11]
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