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| Names | |
|---|---|
| IUPAC name 7-Chloro-2-(4-methoxy-2-methylphenyl)-3,5-dihydropyridazino[4,5-b]quinoline-1,4,10-trione | |
| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
| ChemSpider | |
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| Properties | |
| C19H14ClN3O4 | |
| Molar mass | 383.79 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
ZD-9379 is an antagonist of theN-methyl-D-aspartate receptor. It possesses neuroprotective properties and could potentially be used for the treatment of certain strokes.
ZD-9379 works by antagonizing (blocking) theglycine site on theNMDA receptor,[1][2] because bothglycine (co-agonist) and anagonist at the main site are needed to activate the NMDA receptor, blocking the glycine binding site prevents the receptor from activating.
In rats, ZD-9379 has been tested to helpspreading depression andbrain infarction, results have shown that treatment with ZD-9379 reduced the amount of spreading depressions and the volume of infarcts.[3] Another study was also able to produce similar results.[4]
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