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ZCZ-011

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
ZCZ-011
Identifiers
  • 6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole
CAS Number
PubChemCID
IUPHAR/BPS
ChemSpider
UNII
PDB ligand
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC21H18N2O2S
Molar mass362.45 g·mol−1
3D model (JSmol)
  • Cc1ccc2c([nH]c(c3ccccc3)c2C(C[N+]([O-])=O)c4sccc4)c1
  • InChI=1S/C21H18N2O2S/c1-14-9-10-16-18(12-14)22-21(15-6-3-2-4-7-15)20(16)17(13-23(24)25)19-8-5-11-26-19/h2-12,17,22H,13H2,1H3
  • Key:RJSPNRDBWHHFMH-UHFFFAOYSA-N

ZCZ-011 is a positiveallosteric modulator of thecannabinoidCB1receptor.[1][2]

See also

[edit]

References

[edit]
  1. ^Poklis JL, Clay DJ, Ignatowska-Jankowska BM, Zanato C, Ross RA, Greig IR, et al. (June 2015)."HPLC-MS-MS Determination of ZCZ-011, A Novel Pharmacological Tool for Investigation of the Cannabinoid Receptor in Mouse Brain Using Clean Screen FASt™ Column Extraction".Journal of Analytical Toxicology.39 (5):353–8.doi:10.1093/jat/bkv015.PMC 4542657.PMID 25737338.
  2. ^Ignatowska-Jankowska BM, Baillie GL, Kinsey S, Crowe M, Ghosh S, Owens RA, et al. (December 2015)."A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects".Neuropsychopharmacology.40 (13):2948–59.doi:10.1038/npp.2015.148.PMC 4864630.PMID 26052038.
Phytocannabinoids
(comparison)
Cannabibutols
Cannabichromenes
Cannabicyclols
Cannabidiols
Cannabielsoins
Cannabigerols
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Delta-8-tetrahydrocannabinols
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Endocannabinoids
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cannabinoid
receptor
agonists /
neocannabinoids
Classical cannabinoids
(dibenzopyrans)
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cannabinoids
Adamantoylindoles
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Benzoylindoles
Cyclohexylphenols
Eicosanoids
Indazole-3-
carboxamides
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AllostericCBRTooltip Cannabinoid receptorligands
Endocannabinoid
enhancers

(inactivation inhibitors)
Anticannabinoids
(antagonists/inverse
agonists/antibodies)
Receptor
(ligands)
CB1Tooltip Cannabinoid receptor type 1
Agonists
(abridged,
full list)
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CB2Tooltip Cannabinoid receptor type 2
Agonists
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NAGly
(
GPR18)
Agonists
Antagonists
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Agonists
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Agonists
Transporter
(modulators)
eCBTsTooltip Endocannabinoid transporter
Enzyme
(modulators)
FAAHTooltip Fatty acid amide hydrolase
MAGL
ABHD6
ABHD12
Others
  • Others:2-PG(directly potentiates activity of 2-AG at CB1 receptor)
  • ARN-272(FAAH-like anandamide transporter inhibitor)
See also
Receptor/signaling modulators
Cannabinoids (cannabinoids by structure)
Tryptamines
4-Hydroxytryptamines
andesters/ethers
5-Hydroxy- and
5-methoxytryptamines
N-Acetyltryptamines
α-Alkyltryptamines
Cyclized tryptamines
Isotryptamines
Related compounds
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