Aside from acting, Yoo also ventured into radio. She was theDJ ofLet's Crank Up the Volume from 2011 to 2016. In 2024 she announced her return as a Radio DJ, with the formation of her radio show onYouTube titled,Yoo In Radio.
At the age of 16, Yoo In-na joined an entertainment agency as an apprentice singer in 1998, and had nearly become part of agirl group. After 11 years and five different agencies, she could not be prominent.[2] Yoo said she had difficulty memorizing the dance choreography required ofK-pop singers, and after practicing for eight hours a day, six days a week, she had resigned from becoming an idol.[3]
In 2006, Yoo joinedYG Entertainment as an aspiring actress. She said, "If singing wasn't meant to be, I decided to give acting a go because it seemed fun. I never gave up. A lot of my friends did, though, even though they were prettier and more capable than me."[3] She first came to note in 2009 with thesitcomHigh Kick Through the Roof onMBC.[4] Several supporting roles followed, notably in the 2010 dramaSecret Garden,[5] which she received a Best New Actress award at theBaeksang Arts Awards, and as the second female lead inHong sisters' romantic comedyThe Greatest Love.[6] To maintain public visibility, Yoo Inna joined the cast of the variety showHeroes, which aired from July 18, 2010, to May 1, 2011.[7]
In 2012, Yoo starred in her first leading role in thetvN time-slip romance seriesQueen and I,[14][15][16][17] and in and in 2013, she appeared in the KBS dramaYou Are the Best! and the SBS dramaMy Love from the Star, all of which recorded viewership ratings of over 30% and were greatly loved by viewers. In 2016-2017 she appeared in the tvN dramaGuardian: The Lonely and Great God playing the second female lead. The drama was a commercial success with the final episode recording an 18.68% nationwide audience share, making it the seventh highest-rated drama in Korean cable television history,[18] and she was nominated "Best Supporting Actress" at the10th Korea Drama Awards.
In 2024 Yoo Inna opened her own radio Youtube show titledYoo-In Radio with the first guest, Ko Young-bae from korean band Soran.
In July 2025, followingYG Entertainment’s announcement that it would discontinue its actor management division, Yoo signed her first exclusive contract in 19 years with a new agency, Chorokbaem Entertainment.[19]
Yoo Inna is best friends with fellow singer-actress andYou Are the Best! co-starIU, whom she has known since they met on the television showHeroes in 2010.[20] At a June 7, 2012, fan meeting to mark the end ofQueen and I,Ji Hyun-woo made a surprise public declaration that he was in love with co-star Yoo.[21][22] The declaration was covered significantly by the press in the following days,[23][24][25][26] during which their agencies, and Ji and Yoo had remained quiet on the issue,[27][28] except for a message to his fans that Ji posted onTwitter on June 11.[29][30] Speculation about their relationship status ended on June 17, when gossip website Sportsseoul.com photographed the couple together on a midnight date at a park inBundang,Gyeonggi, where Yoo lives.[31][32] On June 18, Yoo confirmed on her radio show that they were officially dating.[33][34][35] On May 14, 2014, their respective agencies confirmed in a press release that the couple had ended their relationship.[36][37][38]
On January 2019 Yoo secretly donated 30 million won tosalvation army's meal support project for undernourished children.[39]
On February 9, 2023, Yoo donated 30 million won to help in2023 Turkey–Syria earthquake through Hope Bridge National Disaster Relief Association.[40]
On 22 June 2024, Yoo participated in "Can you say it again?" event organised by social welfare organization Snail of Love. Yoo is a Soul Leader, a designation for high-value donors of the social welfare organization Snail of Love.She has donated a total of 230 million won, which was used to support 25 hearing-impaired children by covering the cost ofcochlear implant surgeries and devices.[41]
^Seung-rok Lee (January 3, 2019).[단독] 유인나, 결식 청소년 지원에 남몰래 3천만원 기부했다 [[Exclusive] Yoo In-na secretly donated 30 million won to support undernourished youth.] (in Korean). My daily – viaNaver.
^Yoo Jun-ha (February 9, 2023).튀르키예·시리아 지진 피해에... 한지민·혜리·이용진 등 기부 물결 [Earthquake damage in Turkey and Syria... A wave of donations such as Han Ji-min, Lee Hye-ri, and Lee Yong-jin] (in Korean). E-Daily.Archived from the original on February 9, 2023. RetrievedFebruary 9, 2023 – viaNaver.
^Hong se young (June 24, 2024).유인나 재능기부 또…사랑의달팽이 행사 후기 낭독 [Yoo In-na donates her talents again...] (in Korean). Sports Dongal – viaNaver.
^Shim Eom-hyung (September 10, 2021).유인나, '다큐 3일' 내레이션 참여...'꿀보이스' 활약 예고[공식] [Yoo In-na participates in the narration of 'Documentary 3 Days'... Announcement of 'Honey Voice' [Official]].Spotify News (in Korean).Archived from the original on September 10, 2021. RetrievedSeptember 10, 2021 – viaNaver.
^Lee Min-ji (October 6, 2021).유인나 '창원 K-POP 월드 페스티벌' 단독 MC 확정(공식) [Yoo In-na confirmed as sole MC for 'Changwon K-POP World Festival' (official)].Newsen (in Korean).Archived from the original on October 6, 2021. RetrievedOctober 6, 2021 – viaNaver.
^Park Pan-seok (November 3, 2021).유인나, '시나브로 꿈 조작단' MC 출연...찰떡 케미 예고 [Yoo In-na to appear as MC for 'Sinabro's Dream Manipulator'... Great chemistry notice] (in Korean).OSEN.Archived from the original on November 3, 2021. RetrievedNovember 3, 2021 – viaNaver.
^Jang Woo-young (November 23, 2021).유인나, '더 나은 삶, 우리 함께' 캠페인 참여..따뜻한 목소리로 응원 [Yoo In-na participates in the 'Better Life, Together' campaign.. Cheers with a warm voice] (in Korean).OSEN.Archived from the original on November 23, 2021. RetrievedNovember 23, 2021.
^역사스페셜 "박물관은 살아있다" [History Special "The Museum is Alive"] (in Korean).KBS Media. December 28, 2021.Archived from the original on December 28, 2021. RetrievedDecember 28, 2021.
^Jung Ji-hyun (February 21, 2022).유인나X이용진X아이키, '우리 사이' MC 확정...3월 말 첫 방송 [공식] [Yoo In-na X Lee Yong-jin X Aiki confirmed as MCs for 'Between Us'... First broadcast at the end of March [Official]] (in Korean).MyDaily.Archived from the original on February 21, 2022. RetrievedFebruary 21, 2022 – viaNaver.
^Ha Hyun-Jung (September 1, 2022).유인나·지코·이진호·유정, 데이팅 예능 '체인리액션' MC[공식] [Yoo In-na, Zico, Lee Jin-ho, and Yoo-jeong, dating entertainment 'Chain Reaction' MCs [Official]] (in Korean).MyDaily.Archived from the original on April 21, 2023. RetrievedSeptember 1, 2022 – viaNaver.
^Kim Myung-Mi (September 6, 2022).'아바드림' 유인나-유세윤-김현철, 우주 히어로 변신 포착 ['Abadream' Yoo In-na, Yoo Se-yoon, and Kim Hyun-cheol, transformed into a space hero] (in Korean).OSEN.Archived from the original on September 6, 2022. RetrievedSeptember 6, 2022 – via Nave.
^Cha Hye-young (July 23, 2021).유인나, '헐왓챠파티에' 캠페인 참여...영화 코멘터리 호스트 [Inna Yoo participated in the 'Hull Watch Party' campaign Movie Commentary Host].TenAsia (in Korean).Archived from the original on July 23, 2021. RetrievedJuly 23, 2021 – viaNaver.
^Sang-guen Yoon (February 3, 2025).유인나 11년만 '겟잇뷰티' MC 컴백 확정 "설레고 기뻐요"[공식] [Yoo In-na Confirmed to Return as MC on 'Get It Beauty' After 11 Years: "I'm Excited and Happy" [Official]].Star News (in Korean) – viaNaver.
^Ryu Ji-yoon (April 23, 2022).장현성·유인나, 제23회 JIFF 개막식 사회자로 나선다 [Hyunseong Jang and Inna Yoo to host the 23rd JIFF Opening Ceremony] (in Korean). Dailyan.Archived from the original on April 23, 2022. RetrievedApril 23, 2022 – viaNaver.
^Jang Chang-hwan (December 28, 2011).SBS, '연예대상' 17개 수상 부문 발표 [SBS announces 17 award categories for 'Entertainment Awards'].Naver (in Korean).Archived from the original on December 18, 2022. RetrievedDecember 19, 2022.
^SoompiTV (April 25, 2018),Yoo In na – Best Supporting Actress | 13th Annual Soompi Awards