XDS could refer to:

• Cross Enterprise Document Sharing, a system for sharing clinical documents between healthcare institutions
• Direct Save Protocol, a feature of the X Window System graphical user interface for Unix-like computer operating systems
• Envoy discovery services, seeCloud Native Computing Foundation § Envoy
• Extended Data Services, a US standard for TV metadata transmission
• External Development Summit, an event for the video game industry
• Ottawa station, train station in Ottawa, Ontario, Canada with IATA code XDS used by Air France–KLM's connecting bus service
• Springfield Armory XD-S, a pistol sold in the United States designed for concealed carry
• X-ray diffuse scattering, a materials analysis technique
• X-Digital Systems satellite subcarrier audio format
• Xerox Data Systems, the name for Scientific Data Systems after it was purchased by Xerox Corporation

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