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Wolf Reik

From Wikipedia, the free encyclopedia
German molecular biologist

Wolf Reik
Wolf Reik
NationalityGerman
AwardsEMBO Member[when?]
FMedSci
FRS
Scientific career
Fieldsepigenetics
InstitutionsBabraham Institute
University of Cambridge,
Wellcome Trust Sanger Institute
Websitewww.babraham.ac.uk/our-research/epigenetics/wolf-reik

Wolf ReikFRS[1] is a German-Britishmolecular biologist and an honorary group leader at theBabraham Institute, honorary professor ofEpigenetics at theUniversity of Cambridge and associate faculty at theWellcome Trust Sanger Institute.[2][3][4] He was announced as the director of Altos Labs Cambridge Institute when the company launched on 19 January 2022.[5]

Early life and education

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Reik is the first child of four of Rosemarie Reik (nee Heiles) and Helmut Gottlieb Reik (https://de.wikipedia.org/wiki/Helmut_Reik) who were both physicists. Reik was born in Aachen on 22nd August 1957, attended primary school in Braunschweig, and secondary school in Freiburg. Reik studied Physics and Medicine at the University of Freiburg and completed his medical degree at the University of Hamburg. He obtained his MD in the lab ofRudolf Jaenisch and did postdoctoral work in the lab ofAzim Surani.

Career and research

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Wolf Reik studies how additional information can be added to thegenome through a range of processes collectively calledepigenetics. He discovered some of the key epigenetic mechanisms important for mammalian development, physiology, genome reprogramming, and human diseases. His early work led to the discovery that the molecular mechanism ofgenomic imprinting is based onDNA methylation.[6] He uncoverednon-coding RNA[7] andchromatin looping[8] regulating imprinted genes, which he showed to be involved in fetal nutrition, growth, and disease.[9] He found that the environment influences epigenetic programming in embryos, with changes in gene expression persisting in adults and their offspring.With his collaborators he discovered global epigenetic reprogramming in early embryos and in primordial germ cells10. He found that adult human cells could be substantially rejuvenated by epigenetic reprogramming induced by transient treatment with Yamanaka reprogramming factors11.[10][11]

Awards and honours

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Wolf Reik has received many awards, including:

See also

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References

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  1. ^abAnon (2010)."Wolf Reik's FRS".royalsociety.org. London:Royal Society. Retrieved2 January 2014.
  2. ^"Wolf Reik's group".babraham.ac.uk.Babraham Institute.
  3. ^"Wolf Reik at the Sanger".sanger.ac.uk.Wellcome Trust Sanger Institute.
  4. ^Wolf Reik publications indexed byGoogle ScholarEdit this at Wikidata
  5. ^Labs, Altos."Altos Labs launches with the goal to transform medicine through cellular rejuvenation programming".www.prnewswire.com (Press release). Retrieved8 April 2022.
  6. ^Reik W, Collick A, Norris ML, Barton SC, Surani MA (1987) Genomic imprinting determines methylation of parental alleles in transgenic mice.Nature328, 248-251
  7. ^Smits G, Mungall AJ, Griffiths-Jones S, Smith P, Beury D, Matthews L, Rogers J, Pask AJ, Shaw G, VandeBerg JL, McCarrey JR, Renfree MB, Reik W, DunhamI (2008) Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians.Nature Genetics40, 971-976
  8. ^Murrell A, Heeson S, Reik W (2004) Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops.Nature genetics36, 889-893
  9. ^Constância, Miguel; Hemberger, Myriam; Hughes, Jennifer; Dean, Wendy;Ferguson-Smith, Anne; Fundele, Reinald; Stewart, Francesca; Kelsey, Gavin; Fowden, Abigail; Sibley, Colin;Reik, Wolf (2002). "Placental-specific IGF-II is a major modulator of placental and fetal growth".Nature.417 (6892):945–948.doi:10.1038/nature00819.ISSN 0028-0836.PMID 12087403.S2CID 4421165.(subscription required)
  10. ^Dean, Wendy (2001)."Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos".Proceedings of the National Academy of Sciences.98 (24):13734–13738.Bibcode:2001PNAS...9813734D.doi:10.1073/pnas.241522698.PMC 61110.PMID 11717434.
  11. ^Gill, Diljeet (April 2022)."Multi-omic rejuvenation of human cells by maturation phase transient reprogramming".eLife.11.doi:10.7554/eLife.71624.PMC 9023058.PMID 35390271.
  12. ^"Wolf Reik's page at Academia Europaea". Ae-info.org. Retrieved2 January 2014.
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