 | This articlemay be too technical for most readers to understand. Pleasehelp improve it tomake it understandable to non-experts, without removing the technical details.(January 2021) (Learn how and when to remove this message) |
Warty dyskeratoma, also known as anIsolated dyskeratosis follicularis,[1]: 777 is abenign[2]epidermal proliferation with distinctive histologic findings that may mimic invasive squamous cell carcinoma[3] and commonly manifests as an umbilicated (Having a central mark or depression resembling anavel) lesion with akeratotic plug,[4] WD have some histopathologic similarities toviral warts but it's not caused byHPV and the majority of these lesions display overall histopathologic features consistent with afollicular adnexal neoplasm.[5] Usually limited to thehead,neck,[6]scalp[7] orface andvulva.[6] Lesions are generallysolitary and sporadic and may be associated with afollicular unit.Oral involvement,[4] particularly thehard palate, andgenital involvement have been reported. it can also be thought of as one of the manifestations of focalacantholyticdyskeratosis, an epidermal reaction pattern that can be seen in several disorders, includingDarier's disease andGrover's disease.[8]: 639 But the main Difference between Darier disease and Warty dyskeratoma, is that Darier disease inheriteddermatosis (autosomal dominant) consisting of multiple keratoticpapules on theface,trunk, andextremities, while WD occurs as an isolated, noninherited, single keratotic nodule mainly confined to thehead andneck as mentioned earlier.[6]
Warty dyskeratoma must be differentiated fromvulvar dysplasia,Bowenoid papulosis,squamous carcinoma,condyloma, and other viral-induced squamous lesions.[6]