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| Formula | C19H29ClN2O |
| Molar mass | 336.90 g·mol−1 |
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WY-46824 is anorepinephrine-dopamine reuptake inhibitor related tovenlafaxine. It was disclosed by Paige Mahaney and colleagues fromWyeth in 2008.[1] The compound was mentioned in an earlier article from 2007 but was not the main focus of that study.[2]
WY-46824 has binding affinities of 46 nM for thenorepinephrine transporter (NET), 58 nM for thedopamine transporter (DAT), and 18795 nM for theserotonin transporter (SERT). The racemic mixture of WY-46824 was resolved into its constituent enantiomers, with the (S)-enantiomer being the more active one. The N-desmethyl derivative of WY-46824 also shows similar activity.
