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WNT10A

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

WNT10A

Identifiers

Aliases

WNT10A, OODD, SSPS, STHAG4, Wnt family member 10A

External IDs

OMIM:606268;MGI:108071;HomoloGene:22525;GeneCards:WNT10A;OMA:WNT10A - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q35	Start	218,880,852bp^[1]
Band	2q35	End	218,899,581bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 C4	Start	74,830,675bp^[2]
Band	1\|1 C4	End	74,843,338bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gonad

bone marrow cells

skin of abdomen

skin of leg

granulocyte

lymph node

Pituitary Gland

mucosa of transverse colon

olfactory zone of nasal mucosa

anterior pituitary

Top expressed in

tooth

molar

prostatic epithelium

inner root sheath

gastrula

epithelium of male urethra

enamel knot

urethral gland (male)

corneal stroma

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	frizzled binding signaling receptor binding receptor ligand activity
Cellular component	extracellular region extracellular space
Biological process	skin development odontogenesis tongue development hair follicle development positive regulation of gene expression regulation of odontogenesis of dentin-containing tooth multicellular organism development neural crest cell differentiation neuron differentiation epidermis morphogenesis hair follicle morphogenesis cell fate commitment cellular response to transforming growth factor beta stimulus sebaceous gland development Wnt signaling pathway regulation of signaling receptor activity canonical Wnt signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


80326


22409

Ensembl


ENSG00000135925


ENSMUSG00000026167

UniProt


Q9GZT5


P70701

RefSeq (mRNA)


NM_025216


NM_009518

RefSeq (protein)


NP_079492


NP_033544

Location (UCSC)

Chr 2: 218.88 – 218.9 Mb

Chr 1: 74.83 – 74.84 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Wnt-10a is aprotein that in humans is encoded by theWNT10Agene.^[5]^[6]^[7]

Function

[edit]

TheWNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family.^[5]

Clinical significance

[edit]

WNT10A is strongly expressed in the cell lines ofpromyelocytic leukemia andBurkitt's lymphoma. In addition, it and another family member, theWNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.^[5]

Mutations in the WNT10A gene are associated withSchöpf–Schulz–Passarge syndrome,^[8]hypodontia,^[9] and short anagen hair syndrome.^[10]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000135925 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000026167 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b ^c"Entrez Gene: wingless-type MMTV integration site family".
^Kirikoshi H, Sekihara H, Katoh M (May 2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells".Biochem. Biophys. Res. Commun.283 (4):798–805.doi:10.1006/bbrc.2001.4855.PMID 11350055.
^Adaimy L, Chouery E, Megarbane H, Mroueh S, Delague V, Nicolas E, Belguith H, de Mazancourt P, Megarbane A (October 2007)."Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia".Am. J. Hum. Genet.81 (4):821–8.doi:10.1086/520064.PMC 1973944.PMID 17847007.
^Bohring A, Stamm T, Spaich C, Haase C, Spree K, Hehr U, Hoffmann M, Ledig S, Sel S, Wieacker P, Röpke A (July 2009)."WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes".Am. J. Hum. Genet.85 (1):97–105.doi:10.1016/j.ajhg.2009.06.001.PMC 2706962.PMID 19559398.
^van den Boogaard MJ, Créton M, Bronkhorst Y, van der Hout A, Hennekam E, Lindhout D, Cune M, Ploos van Amstel HK (May 2012)."Mutations in WNT10A are present in more than half of isolated hypodontia cases"(PDF).J. Med. Genet.49 (5):327–31.doi:10.1136/jmedgenet-2012-100750.PMID 22581971.S2CID 8815004. Archived fromthe original(PDF) on 2018-07-23. Retrieved2019-02-16.
^Cesarato, Nicole; Schwieger-Briel, Agnes; Gossmann, Yasmina; Henne, Sabrina K; Hillmann, Kathrin; Frommherz, Leonie H; Wehner, Maria; Xiong, Xing; Thiele, Holger; Oji, Vinzenz; Milani, Donatella; Tantcheva-Poor, Iliana; Giehl, Kathrin; Fölster-Holst, Regina; Teichler, Anne (2023-11-16)."Short anagen hair syndrome: association with mono- and biallelic variants in WNT10A and a genetic overlap with male pattern hair loss".British Journal of Dermatology.189 (6):741–749.doi:10.1093/bjd/ljad314.hdl:20.500.11811/11578.ISSN 0007-0963.

Gelebart P, Anand M, Armanious H, et al. (2008)."Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma".Blood.112 (13):5171–9.doi:10.1182/blood-2008-02-139212.PMC 2597612.PMID 18787224.
Beaty TH, Hetmanski JB, Fallin MD, et al. (2006). "Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations".Hum. Genet.120 (4):501–18.doi:10.1007/s00439-006-0235-9.PMID 16953426.S2CID 7836461.
Nawaz S, Klar J, Wajid M, et al. (2009)."WNT10A missense mutation associated with a complete odonto-onycho-dermal dysplasia syndrome".Eur. J. Hum. Genet.17 (12):1600–5.doi:10.1038/ejhg.2009.81.PMC 2987016.PMID 19471313.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Medland SE, Nyholt DR, Painter JN, et al. (2009)."Common variants in the trichohyalin gene are associated with straight hair in Europeans".Am. J. Hum. Genet.85 (5):750–5.doi:10.1016/j.ajhg.2009.10.009.PMC 2775823.PMID 19896111.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Yerges LM, Klei L, Cauley JA, et al. (2009)."High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men".J. Bone Miner. Res.24 (12):2039–49.doi:10.1359/jbmr.090524.PMC 2791518.PMID 19453261.
Memarian A, Hojjat-Farsangi M, Asgarian-Omran H, et al. (2009). "Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia".Leuk. Lymphoma.50 (12):2061–70.doi:10.3109/10428190903331082.PMID 19863181.S2CID 38835813.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

v t e Signaling pathway:Wnt signaling pathway
Ligand	WNT1 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B WNT10A WNT10B WNT11 WNT16
Receptor	Frizzled LRP5 LRP6
Second messenger	Dishevelled GSK-3 APC Beta-catenin

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