Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Volociximab

From Wikipedia, the free encyclopedia
Monoclonal antibody
Pharmaceutical compound
Volociximab
Monoclonal antibody
TypeWhole antibody
SourceChimeric (mouse/human)
Targetα5β1integrin
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6434H9942N1706O2040S52
Molar mass145501.33 g·mol−1
 ☒NcheckY (what is this?)  (verify)

Volociximab (also known as M200) is achimericmonoclonal antibody jointly developed byPDL BioPharma andBiogen Idec for treatment of a variety of advancedsolid tumors. It binds to and inhibits the functional activity ofα5β1integrin.[1]

It is thought to reduce metastases. Early results show potential inrenal cell cancers.[citation needed]

References

[edit]
  1. ^Ng CM, Bai S, Takimoto CH, Tang MT, Tolcher AW (January 2010). "Mechanism-based receptor-binding model to describe the pharmacokinetic and pharmacodynamic of an anti-α5β1 integrin monoclonal antibody (volociximab) in cancer patients".Cancer Chemotherapy and Pharmacology.65 (2):207–17.doi:10.1007/s00280-009-1023-8.PMID 19468731.S2CID 23035675.

External links

[edit]
Monoclonals for bone, musculoskeletal, circulatory, and neurologic systems
Bone
Human
Humanized
Musculoskeletal
Human
Circulatory
Human
Mouse
Chimeric
Humanized
Neurologic
Human
Humanized
Angiogenesis inhibitor
Humanized
Growth factor
Human
Humanized
Other
Stub icon

Thismonoclonal antibody–related article is astub. You can help Wikipedia byadding missing information.

Stub icon

Thisantineoplastic orimmunomodulatorydrug article is astub. You can help Wikipedia byadding missing information.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Volociximab&oldid=1154682826"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2026 Movatter.jp