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| Formula | C10H21NO7 |
| Molar mass | 267.278 g·mol−1 |
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Voglibose (INN andUSAN, trade nameVoglib, marketed by Mascot Health Series) is analpha-glucosidase inhibitor used for lowering postprandial blood glucose levels in people withdiabetes mellitus.[1] Voglibose is a research product ofTakeda Pharmaceutical Company, Japan's largest pharmaceutical company. Voglibose was discovered in 1981, and was first launched in Japan in 1994,[2] under the trade name BASEN, to improve postprandial hyperglycemia indiabetes mellitus.[3]
Postprandialhyperglycemia (PPHG) is primarily due to first phase insulin secretion. Alpha glucosidase inhibitors delay glucose absorption at the intestine level and thereby prevent sudden surge of glucose after a meal.[2]
There are three major drugs which belong to this class,acarbose,miglitol and voglibose,[2] of which voglibose is the newest.
ACochranesystematic review assessed the effect of alpha-glucosidase inhibitors in people with impairedglucose tolerance, impairedfasting blood glucose, elevated glycated hemoglobin A1c (HbA1c).[4] It was found that there was no conclusive evidence that voglibose compared to diet and exercise or placebo reduced incidence of diabetes mellitus type 2, improvedall-cause mortality, reduced or increased risk of cardiovascular mortality, serious or non-serious adverse events, non-fatalstroke,congestive heart failure, or non-fatalmyocardial infarction.[4]
