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Viqualine

From Wikipedia, the free encyclopedia
Medication
Pharmaceutical compound
Viqualine
Identifiers
  • 4-[3-[(3R,4R)-3-Ethenylpiperidin-4-yl]propyl]-6-methoxyquinoline
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC20H26N2O
Molar mass310.441 g·mol−1
3D model (JSmol)
  • COC1=CC2=C(C=CN=C2C=C1)CCC[C@@H]3CCNC[C@@H]3C=C
  • InChI=1S/C20H26N2O/c1-3-15-14-21-11-9-16(15)5-4-6-17-10-12-22-20-8-7-18(23-2)13-19(17)20/h3,7-8,10,12-13,15-16,21H,1,4-6,9,11,14H2,2H3/t15-,16+/m0/s1 ☒N
  • Key:XFXANHWIBFMEOY-JKSUJKDBSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Viqualine (INN) (developmental code namePK-5078) is anantidepressant andanxiolyticdrug that was never marketed.[1][2][3] It acts as apotent andselectiveserotonin releasing agent (SRA) andserotonin reuptake inhibitor (SRI) similarly topara-chloroamphetamine (PCA).[3][4][5] In addition, viqualine displacesdiazepam from theGABAA receptor and producesbenzodiazepine-like effects, indicating that it is also apositive allosteric modulator of the benzodiazepine site of the GABAA receptor.[3][6] The drug has mainly been researched as a potential treatment foralcoholism.[7][8]

See also

[edit]

References

[edit]
  1. ^Elks J (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1–.ISBN 978-1-4757-2085-3.
  2. ^Faravelli C, Albanesi G, Sessarego A (1988). "Viqualine in resistant depression: a double-blind, placebo-controlled trial".Neuropsychobiology.20 (2):78–81.doi:10.1159/000118477.PMID 3075725.
  3. ^abcPapakostas GI, Fava M (2010).Pharmacotherapy for Depression and Treatment-resistant Depression. World Scientific. pp. 304–.ISBN 978-981-4287-59-3.
  4. ^Le Fur G, Imbault F, Mitrani N, Marquis F, Renault C, Dubroeucq MC, et al. (February 1984). "The 5-hydroxytryptamine-releasing properties of two epimer quinoline derivatives".Neuropharmacology.23 (2A):169–173.doi:10.1016/S0028-3908(84)80010-6.PMID 6717757.S2CID 30380886.
  5. ^Le Fur G, Imbault F, Mitrani N, Marquis F, Renault C, Dubroeucq MC, Gueremy C, Uzan A (February 1984). "The 5-hydroxytryptamine-releasing properties of two epimer quinoline derivatives".Neuropharmacology.23 (2A):169–173.PMID 6717757.
  6. ^Faravelli C, Albanesi G, Sessarego A (1988). "Viqualine in resistant depression: a double-blind, placebo-controlled trial".Neuropsychobiology.20 (2):78–81.doi:10.1159/000118477.PMID 3075725.
  7. ^Naranjo CA, Sellers EM (1989). "Serotonin Uptake Inhibitors Attenuate Ethanol Intake in Problem Drinkers".Recent Developments in Alcoholism. Vol. 7. pp. 255–266.doi:10.1007/978-1-4899-1678-5_13.ISBN 978-1-4899-1680-8.PMID 2522667.
  8. ^Naranjo CA, Sullivan JT, Kadlec KE, Woodley-Remus DV, Kennedy G, Sellers EM (September 1989). "Differential effects of viqualine on alcohol intake and other consummatory behaviors".Clinical Pharmacology and Therapeutics.46 (3):301–309.doi:10.1038/clpt.1989.142.PMID 2673621.S2CID 27080094.
Alcohols
Barbiturates
Benzodiazepines
Carbamates
Flavonoids
Imidazoles
Kava constituents
Monoureides
Neuroactive steroids
Nonbenzodiazepines
Phenols
Piperidinediones
Pyrazolopyridines
Quinazolinones
Volatiles/gases
Others/unsorted
DRAsTooltip Dopamine releasing agents
NRAsTooltip Norepinephrine releasing agents
SRAsTooltip Serotonin releasing agents
Others
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