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Vilanterol

From Wikipedia, the free encyclopedia
Asthma drug – beta-adrenergic agonist
Pharmaceutical compound
Vilanterol
Clinical data
License data
Pregnancy
category
ATC code
Legal status
Legal status
Identifiers
  • 4-{(1R)-2-[(6-{2-[(2,6-Dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol
CAS Number
PubChemCID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.217.751Edit this at Wikidata
Chemical and physical data
FormulaC24H33Cl2NO5
Molar mass486.43 g·mol−1
3D model (JSmol)
  • c1cc(c(c(c1)Cl)COCCOCCCCCCNC[C@@H](c2ccc(c(c2)CO)O)O)Cl
  • InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1
  • Key:DAFYYTQWSAWIGS-DEOSSOPVSA-N

Vilanterol is anultra-long-acting β2-adrenoceptor agonist which was approved in May 2013 in combination withfluticasone furoate for sale asBreo Ellipta byGlaxoSmithKline for the treatment ofchronic obstructive pulmonary disease (COPD).[1][2] The combination is also approved for the treatment ofasthma in Canada, Europe, Japan[3] and New Zealand.[4]

Vilanterol is available in following combinations:

See also

[edit]
  • Salmeterol—the long-acting β2-adrenergic receptor agonist from which vilanterol was derived.

References

[edit]
  1. ^"FDA approves Breo Ellipta to treat chronic obstructive pulmonary disease".Food and Drug Administration. Archived fromthe original on June 7, 2013. Retrieved10 May 2013.
  2. ^McKeage K (September 2014). "Fluticasone furoate/vilanterol: a review of its use in chronic obstructive pulmonary disease".Drugs.74 (13):1509–22.doi:10.1007/s40265-014-0269-6.PMID 25074268.S2CID 29379731.
  3. ^Syed YY (March 2015). "Fluticasone furoate/vilanterol: a review of its use in patients with asthma".Drugs.75 (4):407–18.doi:10.1007/s40265-015-0354-5.PMID 25648266.S2CID 24563680.
  4. ^Zealand (www.bka.co.nz), Site designed and developed by bka interactive ltd, Auckland, New (22 June 2019)."Fluticasone and vilanterol | Health Navigator NZ".Health Navigator New Zealand.{{cite web}}: CS1 maint: multiple names: authors list (link)
Adrenergics,inhalants
Short-acting β2 agonists
Long-acting β2 agonists
Ultra-long-acting β2 agonists
Other
Glucocorticoids
Anticholinergics/
muscarinic antagonist
Mast cell stabilizers
Xanthines
Eicosanoid inhibition
Leukotriene antagonists
Arachidonate 5-lipoxygenase inhibitors
Thromboxane receptor antagonists
Non-xanthinePDE4 inhibitors
Others/unknown
Combination products


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