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Vesicular glutamate transporter 1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
SLC17A7
Identifiers
AliasesSLC17A7, BNPI, VGLUT1, solute carrier family 17 member 7
External IDsOMIM:605208;MGI:1920211;HomoloGene:113454;GeneCards:SLC17A7;OMA:SLC17A7 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SLC17A7
Genomic location for SLC17A7
Band19q13.33Start49,429,401bp[1]
End49,442,360bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SLC17A7
Genomic location for SLC17A7
Band7|7 B3Start44,813,373bp[2]
End44,825,566bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • right frontal lobe

  • superior frontal gyrus

  • Brodmann area 10

  • frontal pole

  • Region I of hippocampus proper

  • middle temporal gyrus

  • Brodmann area 46

  • dorsolateral prefrontal cortex

  • orbitofrontal cortex
Top expressed in
  • neural layer of retina

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • superior frontal gyrus

  • prefrontal cortex

  • piriform cortex

  • cerebellar cortex

  • hippocampus proper

  • primary motor cortex

  • subiculum
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57030

72961

Ensembl

ENSG00000104888

ENSMUSG00000070570

UniProt

Q9P2U7

Q3TXX4

RefSeq (mRNA)

NM_020309

NM_182993

RefSeq (protein)

NP_064705

NP_892038

Location (UCSC)Chr 19: 49.43 – 49.44 MbChr 7: 44.81 – 44.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vesicular glutamate transporter 1 (VGLUT1) is aprotein that in humans is encoded by theSLC17A7gene.[5][6][7]

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphatecotransporter and they appear to form a distinct class within the Na+/Picotransporter family.[7]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000104888 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000070570 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter".J Neurochem.66 (6):2227–38.doi:10.1046/j.1471-4159.1996.66062227.x.PMID 8632143.S2CID 23177236.
  6. ^Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000)."Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter".J Neurochem.74 (6):2622–5.doi:10.1046/j.1471-4159.2000.0742622.x.PMID 10820226.S2CID 37857748.
  7. ^ab"Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".

Further reading

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

By group
SLC1–10
(1):
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SLC11–20
(11):
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SLC21–30
(21):
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SLC31–40
(31):
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SLC41–48
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SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
Transporter
EAATsTooltip Excitatory amino acid transporters
vGluTsTooltip Vesicular glutamate transporters
Enzyme
GAHTooltip Glutamine aminohydrolase (glutaminase)
ASTTooltip Aspartate aminotransferase
ALTTooltip Alanine aminotransferase
GDHTooltip Glutamate dehydrogenase
GSTooltip Glutamine synthetase
GADTooltip Glutamate decarboxylase


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