Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

Vesicular acetylcholine transporter

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens
SLC18A3
Identifiers
AliasesSLC18A3, VACHT, solute carrier family 18 member A3, CMS21
External IDsOMIM:600336;MGI:1101061;HomoloGene:11022;GeneCards:SLC18A3;OMA:SLC18A3 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for SLC18A3
Genomic location for SLC18A3
Band10q11.23Start49,610,310bp[1]
End49,612,720bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for SLC18A3
Genomic location for SLC18A3
Band14 B|14 19.4 cMStart32,184,395bp[2]
End32,186,807bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • putamen

  • caudate nucleus

  • placenta

  • muscle layer of sigmoid colon

  • nucleus accumbens

  • hypothalamus

  • C1 segment

  • muscle tissue

  • pituitary gland
Top expressed in
  • lumbar subsegment of spinal cord

  • facial motor nucleus

  • anterior horn of spinal cord

  • habenula

  • neural tube

  • embryo

  • superior frontal gyrus

  • basal plate

  • embryo

  • neural layer of retina
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6572

20508

Ensembl

ENSG00000187714

ENSMUSG00000100241

UniProt

Q16572

O35304
Q3TYJ1

RefSeq (mRNA)

NM_003055

NM_021712

RefSeq (protein)

NP_003046

NP_068358

Location (UCSC)Chr 10: 49.61 – 49.61 MbChr 14: 32.18 – 32.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TheVesicular acetylcholine transporter (VAChT) is aneurotransmitter transporter which is responsible for loadingacetylcholine (ACh) intosecretory organelles inneurons making acetylcholine available for secretion.[5][6] It is encoded bySolute carrier family 18, member 3 (SLC18A3)gene, located within the firstintron of thecholine acetyltransferase gene. VAChT is able to transport ACh into vesicles by relying on an exchange betweenprotons (H+) that were previously pumped into the vesicle diffusing out, thus acting as anantiporter. ACh molecules are then carried into the vesicle by the action of exiting protons.[7] Acetylcholine transport utilizes a proton gradient established by avacuolar ATPase.

VAChT uptake inhibitors

[edit]

Radiolabeled compounds

[edit]

PET imaging of the VAChT may provide insights into early diagnosis ofAlzheimer's disease.

  • (−)-trans-2-Hydroxy-3-(4-(4-[18F]fluorobenzoyl)piperidino)tetralin; racemate:Ki = 2.70 nM for VAChT, 191 nM forσ1, and 251 nM for σ2[8]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000187714 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000100241 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Erickson JD, Varoqui H (Dec 2000)."Molecular analysis of vesicular amine transporter function and targeting to secretory organelles".FASEB Journal.14 (15):2450–8.doi:10.1096/fj.00-0206rev.PMID 11099462.S2CID 15305436.
  6. ^Weihe E, Tao-Cheng JH, Schäfer MK, Erickson JD, Eiden LE (Apr 1996)."Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles".Proceedings of the National Academy of Sciences of the United States of America.93 (8):3547–52.Bibcode:1996PNAS...93.3547W.doi:10.1073/pnas.93.8.3547.PMC 39647.PMID 8622973.
  7. ^Waymire J."Storage of ACh". University of Texas Medical Center.
  8. ^Tu Z, Efange SM, Xu J, Li S, Jones LA, Parsons SM, Mach RH (Mar 2009)."Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter".Journal of Medicinal Chemistry.52 (5):1358–69.doi:10.1021/jm8012344.PMC 2765529.PMID 19203271.

Further reading

[edit]

External links

[edit]
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
SLC41–48
(41):
(42):
(43):
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
Vesicular
Other
Enzyme
(modulators)
ChATTooltip Choline acetyltransferase
AChETooltip Acetylcholinesterase
BChETooltip Butyrylcholinesterase
Transporter
(modulators)
CHTTooltip Choline transporter
VAChTTooltip Vesicular acetylcholine transporter
Release
(modulators)
Inhibitors
Enhancers


Stub icon

Thismembrane protein–related article is astub. You can help Wikipedia byadding missing information.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Vesicular_acetylcholine_transporter&oldid=1215825068"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2026 Movatter.jp