Synaptobrevin
Three different views of the high resolution structure of a truncated neuronal SNARE complex. Legend: synaptobrevin-2 (red), Syntaxin-1 (pink), SNAP-25 (purple).
Identifiers
Symbol	Synaptobrevin
Pfam	PF00957
InterPro	IPR016444
PROSITE	PDOC00368
SCOP2	1sfc /SCOPe /SUPFAM
OPM superfamily	197
OPM protein	4wy4
Membranome	198
Available protein structures: Pfam   structures /ECOD   PDB RCSB PDB;PDBe;PDBj PDBsum structure summary

Vesicle associated membrane proteins (VAMPs) are a family ofSNARE proteins with similar structure, and are mostly involved invesicle fusion.

• VAMP1 andVAMP2 proteins known assynaptobrevins are expressed in brain and are constituents of the synaptic vesicles, where they participate inneurotransmitter release.
• VAMP3 (known as cellubrevin) is ubiquitously expressed and participates in regulated and constitutiveexocytosis as a constituent of secretory granules and secretory vesicles.
• VAMP5 andVAMP7 participate in constitutive exocytosis.
  • VAMP5 is a constituent of secretory vesicles, myotubes and tubulovesicular structures.
  • VAMP7 is found both in secretory granules and endosomes.
• VAMP8 (known as endobrevin) participates inendocytosis and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells.
• VAMP4 is involved in transport from the Golgi.^[1]

• Vesicle-Associated+Membrane+Protein+1 at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

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