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Velagliflozin

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Medication

Pharmaceutical compound

Velagliflozin
Clinical data

Trade names	Senvelgo
License data	US DailyMed: Velagliflozin
Routes of administration	By mouth
ATCvet code	QA10BK90 (WHO)
Legal status
Legal status	CA: ℞-only^[1] US: ℞-only^[2] EU: Rx-only [3]
Identifiers
IUPAC name 2-[(4-cyclopropylphenyl)methyl]-4-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]benzonitrile
CAS Number	946525-65-1
PubChemCID	24862817
ChemSpider	58827717
UNII	FV2YU8SL0P EQE2P2T77I
Chemical and physical data
Formula	C₂₃H₂₅NO₅
Molar mass	395.455 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CC1C2=CC=C(C=C2)CC3=C(C=CC(=C3)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C#N
InChI InChI=1S/C23H25NO5/c24-11-17-8-7-16(23-22(28)21(27)20(26)19(12-25)29-23)10-18(17)9-13-1-3-14(4-2-13)15-5-6-15/h1-4,7-8,10,15,19-23,25-28H,5-6,9,12H2/t19-,20-,21+,22-,23+/m1/s1 Key:SENUNDCNOYAWGN-ZQGJOIPISA-N Key:UWKBFNWQMSGEPG-ZHNCTCHCSA-N

Velagliflozin, sold under the brand nameSenvelgo, is anantidiabetic medication used for the treatment of cats.^[2]^[4]^[5] Velagliflozin is asodium-glucose cotransporter 2 (SGLT2) inhibitor.^[6] It is takenby mouth.^[2]

Velagliflozin isindicated to improve glycemic control in otherwise healthy cats with diabetes not previously treated with insulin.^[2]^[4]^[6]

fast-acting	Insulin aspart Insulin glulisine Insulin lispro
short-acting	Regular insulin^#
long-acting	Insulin detemir^# Insulin glargine^# (+lixisenatide) NPH insulin Lente insulin^‡ Ultralente insulin^‡
ultra-long-acting	Insulin degludec^# (+insulin aspart,+liraglutide) Insulin icodec^† (+semaglutide)
inhalable	Exubera^‡ Afrezza
Oral	Insulin tregopil^†

Non-insulins

Biguanides	Buformin^‡ Metformin^# Phenformin^‡
TZDs/"glitazones" (PPAR)	Ciglitazone^§ Darglitazone^§ Englitazone^§ Lobeglitazone Netoglitazone^§ Pioglitazone Rivoglitazone^† Rosiglitazone Troglitazone^‡
Dual PPAR agonists	Aleglitazar^† Muraglitazar^§ Saroglitazar Tesaglitazar^§
Amylin analogues andDACRAs	Cagrilintide^§ Pramlintide

Sulfonylureas	1st generation:Acetohexamide Carbutamide Chlorpropamide Glycyclamide Metahexamide Tolazamide Tolbutamide 2nd generation:Glibenclamide (glyburide) Glibornuride Glicaramide Gliclazide^# Glimepiride Glipizide Gliquidone Glisoxepide Glyclopyramide
Meglitinides/"glinides"	Mitiglinide Nateglinide Repaglinide

GLP1 poly-agonist peptides	Mazdutide (GLP-1/GCGR) Retatrutide^§ (GLP-1/GIP/GCGR) Tirzepatide (GLP-1/GIP)

Other

Aldose reductase inhibitors	Epalrestat Fidarestat^§ Ranirestat^† Tolrestat^‡ Zenarestat^§
Alpha-glucosidase inhibitors	Acarbose Miglitol Voglibose
SGLT2 inhibitors/"gliflozins"	Canagliflozin Dapagliflozin Empagliflozin^# Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin^§ Sergliflozin^§ Sotagliflozin Tofogliflozin^† Velagliflozin
Other	Benfluorex^‡ Bromocriptine Imeglimin

v t e Sodium-glucose transporter modulators
SGLT1Tooltip Sodium-glucose transporter 1	Inhibitors:Phloretin Phlorizin T-1095 T-1095A
SGLT2Tooltip Sodium-glucose transporter 2	Inhibitors:Atigliflozin Bexagliflozin Canagliflozin Dapagliflozin Empagliflozin Enavogliflozin Ertugliflozin Henagliflozin Ipragliflozin Janagliflozin Licogliflozin Luseogliflozin Mizagliflozin Phloretin Phlorizin Remogliflozin Sergliflozin T-1095 T-1095A Tofogliflozin Velagliflozin Antisense oligonucleotides:ISIS-388626
SGLT1Tooltip Sodium-glucose transporter 1 &SGLT2Tooltip Sodium-glucose transporter 2	Inhibitors:Sotagliflozin
See also:Receptor/signaling modulators

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