There are two knownreceptors for thevasoactive intestinal peptide (VIP) termed VPAC₁ and VPAC₂.^[1][2] These receptors bind both VIP andpituitary adenylate cyclase-activating polypeptide (PACAP) to some degree. Both receptors are members of the 7 transmembraneG protein-coupled receptor family.

VPAC₁ is distributed widely in theCNS,liver,lung,intestine andT-lymphocytes.

VPAC₂ is found in theCNS,pancreas,skeletal muscle,heart,kidney,adipose tissue,testis, andstomach.

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) receptors are activated by the endogenous peptides VIP, PACAP-38, PACAP-27,peptide histidine isoleucineamide (PHI), peptide histidine methionineamide (PHM) and peptide histidine valine (PHV). “PACAP type II receptors” (VPAC1 and VPAC2 receptors) display comparable affinity for PACAP and VIP, whereas PACAP-27 and PACAP-38 are >100 fold more potent than VIP as agonists of most isoforms of the PAC1 receptor.^[3]

• "VIP and PACAP Receptors".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2007-10-25.
• Receptors,+Vasoactive+Intestinal+Peptide at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

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