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Amlodipine/valsartan

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(Redirected fromValsartan/hydrochlorothiazide/amlodipine)
Antihypertensive medication

Pharmaceutical compound
Amlodipine/valsartan
Combination of
AmlodipineCalcium channel blocker
ValsartanAngiotensin II receptor antagonist
Clinical data
Trade namesExforge, Copalia, Dafiro
AHFS/Drugs.comProfessional Drug Facts
License data
Pregnancy
category
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChemCID
ChemSpider
KEGG
CompTox Dashboard(EPA)
  (verify)

Amlodipine/valsartan, sold under the brand nameExforge among others, is ablood pressure loweringcombination drug. It containsamlodipine, as the besilate, adihydropyridine-typecalcium channel blocker, andvalsartan, anangiotensin II receptor antagonist.[6] This combination is usually well tolerated and effective for the reduction of blood pressure.[7]

The combination was approved for medical use in the European Union in January 2007,[3] and in the United States in June 2007.[8]

The combination is also available withhydrochlorothiazide.[9][10] It was approved for medical use in the United States in April 2009,[11] and in the European Union in November 2009.[12][13][14] The combination of amlodipine/valsartan with hydrochlorothiazide is on theWorld Health Organization's List of Essential Medicines.[15]

References

[edit]
  1. ^"Amlodipine / valsartan (Exforge) Use During Pregnancy".Drugs.com. 11 July 2019. Retrieved13 February 2020.
  2. ^"Exforge- amlodipine besylate and valsartan tablet, film coated".DailyMed. 12 June 2019. Retrieved12 February 2020.
  3. ^ab"Exforge EPAR".European Medicines Agency (EMA). 17 January 2007. Retrieved26 August 2024.
  4. ^"Copalia EPAR".European Medicines Agency (EMA). 16 January 2007. Retrieved26 August 2024.
  5. ^"Dafiro EPAR".European Medicines Agency (EMA). 16 January 2007. Retrieved26 August 2024.
  6. ^"Valsartan Monograph for Professionals".Drugs.com. American Society of Health-System Pharmacists. Retrieved3 March 2019.
  7. ^Eckert S, Freytag SB, Müller A, Klebs SH (September 2013). "Meta-analysis of three observational studies of amlodipine/valsartan in hypertensive patients with additional risk factors".Blood Pressure.22 (sup1):11–21.doi:10.3109/08037051.2013.793891.PMID 23713686.S2CID 25814898.
  8. ^"Drug Approval Package: Exforge (amlodipine and valsartan) NDA #021990". U.S.Food and Drug Administration (FDA). 3 October 2008. Retrieved19 September 2021.
  9. ^"Exforge HCT- amlodipine valsartan and hydrochlorothiazide tablet, film coated".DailyMed. Retrieved12 February 2020.
  10. ^"Amlodipine, Valsartan, and Hydrochlorothiazide". Drugs.com.
  11. ^"Drug Approval Package: Exforge HCT (Amlodipine, Valsartan, Hydrochlorothiazide) Tablets NDA #022314". U.S.Food and Drug Administration (FDA). 2 September 2009. Archived fromthe original on 13 February 2017. Retrieved19 September 2021.
  12. ^"Exforge HCT EPAR".European Medicines Agency (EMA). 16 October 2009. Retrieved26 August 2024.
  13. ^"Copalia HCT EPAR".European Medicines Agency (EMA). 4 November 2009. Retrieved26 August 2024.
  14. ^"Dafiro HCT EPAR".European Medicines Agency (EMA). 4 November 2009. Retrieved26 August 2024.
  15. ^The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list. Geneva:World Health Organization. 2025.hdl:10665/382243.
ACE inhibitors
("-pril")
AIIRAs
("-sartan")
Renin inhibitors
("-kiren")
DualACE/NEP inhibitors
Neprilysin inhibitors
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