 | |
| Names | |
|---|---|
| IUPAC name 3-Amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide | |
| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
| ChemSpider | |
| |
| |
| Properties | |
| C18H17N3O3S | |
| Molar mass | 355.41 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
VU-0152099 is a positive allosteric modulator of theM4 receptor used in scientific research.
VU-0152099 is a positive allosteric modulator acting at M4 receptors,[1] it lacks agonist activity, which means it cannot activate the receptor on its own, but can potentiate the activity of M4 receptor agonists such as acetylcholine.
In rats, VU-0152099 is able to decrease self-administration of cocaine[2] and reverse hyperlocomotion induced by amphetamine.[1]
These tests show that VU-0152099 could potentially be developed as a treatment for addiction to stimulants.
