| Vaccine description | |
|---|---|
| Target | SARS-CoV-2 |
| Vaccine type | Protein subunit |
| Clinical data | |
| Other names | SARS-CoV-2 Sclamp |
| Routes of administration | Intramuscular |
| Legal status | |
| Legal status |
|
| Part ofa series on the |
| COVID-19 pandemic |
|---|
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|
Medical response |
|
.svg) COVID-19 portal |
V451 was aCOVID-19 vaccine candidate developed by theUniversity of Queensland and the Australian pharmaceutical companyCSL Limited. The vaccine candidate used the University of Queensland'smolecular clamp technology[1] and theMF59adjuvant.[2]
V451 is a proteinsubunit vaccine. As part of the vaccine's design, researchers added "a fragment of one protein found on the HIV virus"[3] as a "ground-breakingmolecular clamp technology".[4]
The development of the vaccine was cancelled on 11 December 2020 during itsPhase I trial, after a number of trial participants were found to givefalse positive test results forHIV antibodies when they did not in fact have HIV.[5][6] This was due to the HIV virus fragment used as a molecular clamp leading to "a partial antibody response" to HIV. This is an undesirable outcome as it will interfere with futureHIV screening tests for affected participants.[7]
Nine days prior to the termination, on 2 December, the firstemergency use authorisation had been granted to a COVID-19 vaccine; thePfizer–BioNTech COVID-19 vaccine in the United Kingdom.[8] Following the termination of V451, vaccine production capacity by CSL Limited was diverted to theOxford–AstraZeneca COVID-19 vaccine.[9]
