Theuterotubal junction is the connection between the endometrial cavity of theuterus and thefallopian tube (uterine tube) at the proximal tubal opening, the beginning of the intramural part of the fallopian tube. Histologically, the endometrialepithelium changes over tociliated tubal epithelium.
Patency of the uterotubal junction is necessary for normal reproduction. The tubes can get blocked here by infection (salpingitis) and surgical intervention may be necessary.
Mouse studies have indicated that selective passage of individualspermatozoa may occur at this junction,[1] with abnormal morphology being identified as a significant selection criterion, leading to predominantly normalsperm passing towards theovum.[2] Absence of the proteincalmegin has also been suggested as a critical factor for reliable sperm passage.[1]
The uterotubal junction is accessible byhysteroscopy and the entry point for tubalcannulation andfalloposcopy. Contraceptive methods have been developed to block the uterotubal junction.
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