Aunibrow (ormonobrow; calledsynophrys in medicine) is a single eyebrow created when the twoeyebrows meet in the middle above the bridge of thenose.^[1] Thehair above the bridge of the nose is of the same color and thickness as the eyebrows, such that they converge to form one uninterrupted line of hair.

The wordmonobrow first appeared in print in 1968,^[2] and the adjectival formmonobrowed followed in 1973, inMartin Amis' novelThe Rachel Papers.^[3] The first known use of the wordunibrow was in 1981.^[4]

Some nations prize the unibrow. It is a sign of beauty among BaluchiOmanis, whose women sometimes draw a black line joining the brows as a part of their routine makeup to fake a unibrow. A study found the prevalence of synophrys to be at 11.87% in theOmani population.^[5] InTajikistan, where the unibrow is similarly viewed as attractive, some women dry and extract an herb known locally asusma and daub it onto their brows to mimic one.^[6] Urban women may do the same with akohl liner or a kajal pen.^[7]

The unibrow has largely been seen as undesirable in the Americas and Europe, with the hairs oftenplucked,shaved, orwaxed away.^[8][9]Exceptions include the artistFrida Kahlo, famous for her unibrow, which she often depicted in self-portraits,^[10][11] and the Greek-Cypriot modelSophia Hadjipanteli.^[12]

The unibrow is also the trademark of the NBA playerAnthony Davis,^[13] the football playerMarouane Fellaini, and the YouTuberElectroBOOM. The boxerRoberto Elizondo famously sported a unibrow during his professional career.^[14]

The unibrow is a genetic trait^[15] associated with thePAX3 gene; rare mutations of PAX3 have been shown to causeWaardenburg syndrome type 1 (85% of patients with this condition have a unibrow).^[16]

A unibrow is part of normal human variation, but can also stem from developmental disorders. A unibrow is a recognized feature ofCornelia De Lange syndrome, a genetic disorder whose main features include moderate to severe learning difficulties, limb abnormalities such asoligodactyly (fewer than normal fingers or toes), andphocomelia (malformed limbs), and facial abnormalities including a longphiltrum (the slight depression/line between the nose and mouth).

Other medical conditions associated with a unibrow include:^[17]

• 3MC syndrome 1
• Acromegaloid facial appearance syndrome
• Acromesomelic dysplasia 4
• Amaurosis-hypertrichosis syndrome
• Arrhinia withchoanal atresia andmicrophthalmia syndrome
• Autosomal recessivespinocerebellar ataxia 17
• Blepharophimosis-impaired intellectual development syndrome
• Blepharophimosis-ptosis-esotropia-syndactyly-short stature syndrome
• Brachycephaly,trichomegaly, anddevelopmental delay
• Chromosome 1p36 deletion syndrome
• Coffin-Siris syndrome 12
• Cognitive impairment –coarse facies –heart defects –obesity – pulmonary involvement –short stature –skeletal dysplasia syndrome
• Congenital muscular hypertrophy-cerebral syndrome

• Cornelia de Lange syndrome 1–5
• Corpus callosum agenesis-abnormal genitalia syndrome
• Cortical dysplasia, complex, with other brain malformations 11
• Deafness,cataract, impairedintellectual development, andpolyneuropathy
• Deficiency of transaldolase
• DeSanto-Shinawi syndrome due toWACpoint mutation
• Developmental and epilepticencephalopathy 23, 66, 83, 84, 85 (with or without midline brain defects), 100, and 105 (withhypopituitarism)
• Developmental delay with variableintellectual disability anddysmorphic facies
• Developmental delay,impaired speech, andbehavioral abnormalities
• Diamond-Blackfan anemia 21
• Early-onset progressive diffusebrain atrophy-microcephaly-muscle weakness-optic atrophy syndrome
• Epilepsy,X-linked 2, with or without impaired intellectual development and dysmorphic features
• Epilepsy-telangiectasia syndrome
• Focal segmental glomerulosclerosis and neurodevelopmental syndrome
• Fontaineprogeroid syndrome
• Goldberg-Shprintzen megacolon syndrome
• Growth delay due toinsulin-like growth factor I resistance
• Hajdu-Cheney syndrome
• Hennekam lymphangiectasia-lymphedema syndrome 3
• Holoprosencephaly 5, 7, and 11

• Hypotonia,ataxia, and delayed development syndrome
• Intellectual developmental disorder 61
• Intellectual developmental disorder with or withoutperipheral neuropathy
• Intellectual developmental disorder,autosomal dominant 64 and 65
• Intellectual developmental disorder, autosomal recessive 68
• Intellectual developmental disorder, X-linked, syndromic, with pigmentarymosaicism and coarse facies
• Intellectual disability, autosomal dominant 29, 30, 34, 43, 48, and 52
• Intellectual disability, autosomal recessive 5, 13, 16, 45, 46, and 61
• Intellectual disability, X-linked 21, 73, 97, and 106
• Intellectual disability, X-linked, syndromic 33
• Intellectual disability-brachydactyly-Pierre Robin syndrome
• Intellectual disability-facial dysmorphism syndrome due toSETD5haploinsufficiency
• Joubert syndrome 35
• KBG syndrome
• Kleefstra syndrome 1
• Lissencephaly 6 with microcephaly
• Macrothrombocytopenia-lymphedema-developmental delay-facial dysmorphism-camptodactyly syndrome
• Mandibulofacial dysostosis-macroblepharon-macrostomia syndrome
• Marshall-Smith syndrome
• Microcephaly 4, primary, autosomal recessive
• Midface hypoplasia,hearing impairment,elliptocytosis, andnephrocalcinosis
• Mitochondrial complex 4 deficiency, nuclear type 20
• Mitochondrial complex III deficiency nuclear type 7

• Mucopolysaccharidosis, MPS-III-A to -D
• Neurodevelopmental disorder with dysmorphic facies and variableseizures
• Neurodevelopmental disorder with facial dysmorphism,absent language, and pseudo-pelger-huet anomaly
• Neurodevelopmental disorder withgrowth retardation, dysmorphic facies, and corpus callosum abnormalities
• Neurodevelopmental disorder with microcephaly, short stature, andspeech delay
• Neurodevelopmental disorder with severemotor impairment and absent language
• Neurodevelopmental disorder withspasticity and poor growth
• Neurodevelopmental disorder with spasticity,cataracts, andcerebellar hypoplasia
• Periventricular nodular heterotopia 9
• Pontocerebellar hypoplasia type 7, 8, and 10
• Primrose syndrome
• Severefeeding difficulties-failure to thrive-microcephaly due toASXL3 deficiency syndrome
• Sialuria
• Skin creases, congenital symmetric circumferential, 2
• Smith-Magenis syndrome
• Spondyloepimetaphyseal dysplasia, Genevieve type
• Spondyloepiphyseal dysplasia,sensorineural hearing loss, impairedintellectual development, andleber congenital amaurosis
• SyndromicX-linked intellectual disability Chudley-Schwartz type
• Syndromic X-linked intellectual disability Nascimento type
• Syndromic X-linked intellectual disability Siderius type
• Syndromic X-linked intellectual disability Snyder type
• Trigonocephaly 1
• Uruguay Faciocardiomusculoskeletal syndrome
• Waardenburg syndrome types 1, 2A, and 3
• Wiedemann-Steiner syndrome
• Zimmermann-Laband syndrome 1, 2, and 3

• Glabella

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