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Ulobetasol

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Ulobetasol
Clinical data
Trade namesUltravate
Other names(6S,8S,9S,10S,11S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one, halobetasol (USANUS)
AHFS/Drugs.comProfessional Drug Facts
MedlinePlusa601060
ATC code
Identifiers
  • (6α,11β,16β)-21-Chloro-6,9-difluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC22H27ClF2O4
Molar mass428.90 g·mol−1
3D model (JSmol)
  • ClCC(=O)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@@H]3C)C)C
  • InChI=1S/C22H27ClF2O4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1 checkY
  • Key:LEHFPXVYPMWYQD-XHIJKXOTSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Ulobetasol (INN) orhalobetasol (USAN) is acorticosteroid used to treatpsoriasis.[1][2] It is a class I corticosteroid under the US classification and a group III corticosteroid under international classification, the most potent group of such drugs.[3][4]

Ulobetasol propionate is usually supplied as a 0.05% topical cream.[1] Ulobetasol is the strongest topical steroid available.[citation needed] It is also sold withtazarotene with 0.01% halobetasol and 0.045%tazarotene as a lotion branded asDuobrii (Bausch Health).

It is available as ageneric medication.[5]

References

[edit]
  1. ^ab"Ultravate product monograph"(PDF). Retrieved2021-01-04.
  2. ^DrugBankDB00596. Retrieved 2020-01-04.
  3. ^Pearce DJ, Spencer L, Hu J, Balkrishnan R, Fleischer AB, Feldman SR (July 2004). "Class I topical corticosteroid use by psoriasis patients in an academic practice".The Journal of Dermatological Treatment.15 (4):235–8.doi:10.1080/09546630410033745.PMID 15764038.S2CID 2757493.
  4. ^ATC codeD07AC21 (WHO). Retrieved 2020-01-04.
  5. ^"Ulobetasol international".Drugs.com. 10 August 2020. Retrieved15 August 2020.

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