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UQCRC1

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

UQCRC1

Identifiers

Aliases

UQCRC1, D3S3191, QCR1, UQCR1, ubiquinol-cytochrome c reductase core protein I, ubiquinol-cytochrome c reductase core protein 1, PKNPY

External IDs

OMIM:191328;MGI:107876;HomoloGene:2525;GeneCards:UQCRC1;OMA:UQCRC1 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p21.31	Start	48,599,002bp^[1]
Band	3p21.31	End	48,610,976bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9 F2\|9 59.63 cM	Start	108,765,701bp^[2]
Band	9 F2\|9 59.63 cM	End	108,778,691bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

apex of heart

left ventricle

right ventricle

triceps brachii muscle

myocardium of left ventricle

gastrocnemius muscle

muscle of thigh

mucosa of transverse colon

right auricle

vastus lateralis muscle

Top expressed in

proximal tubule

heart

right kidney

muscle tissue

muscle of thigh

skeletal muscle tissue

quadriceps femoris muscle

human kidney

neural layer of retina

duodenum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	ubiquinol-cytochrome-c reductase activity protein-containing complex binding zinc ion binding metal ion binding catalytic activity metalloendopeptidase activity ubiquitin protein ligase binding
Cellular component	mitochondrial respiratory chain complex III membrane myelin sheath mitochondrion mitochondrial respirasome mitochondrial inner membrane respirasome cytosol
Biological process	protein processing response to activity aerobic respiration oxidative phosphorylation response to alkaloid mitochondrial electron transport, ubiquinol to cytochrome c proton transmembrane transport proteolysis
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


7384


22273

Ensembl


ENSG00000010256


ENSMUSG00000025651

UniProt


P31930


Q9CZ13

RefSeq (mRNA)


NM_003365


NM_025407

RefSeq (protein)


NP_003356


NP_079683

Location (UCSC)

Chr 3: 48.6 – 48.61 Mb

Chr 9: 108.77 – 108.78 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cytochrome b-c1 complex subunit 1, mitochondrial is aprotein that in humans is encoded by theUQCRC1gene.^[5]^[6]

Its gene product is a subunit of the respiratory chain proteinUbiquinol Cytochrome c Reductase (UQCR,Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene,MTCYTB (mitochondrialcytochrome b) and ten nuclear genes:UQCRC1,UQCRC2,Cytochrome c1,UQCRFS1 (Rieske protein),UQCRB, "11kDa protein",UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000010256 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000025651 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hoffman GG, Lee S, Christiano AM, Chung-Honet LC, Cheng W, Katchman S, Uitto J, Greenspan DS (Nov 1993)."Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase".J Biol Chem.268 (28):21113–9.doi:10.1016/S0021-9258(19)36900-5.PMID 8407948.
^"Entrez Gene: UQCRC1 ubiquinol-cytochrome c reductase core protein I".

Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T (1991)."Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system".J. Biol. Chem.266 (4):2333–8.doi:10.1016/S0021-9258(18)52248-1.PMID 1846623.
Broger C, Nałecz MJ, Azzi A (1980). "Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain".Biochim. Biophys. Acta.592 (3):519–27.doi:10.1016/0005-2728(80)90096-1.PMID 6251869.
Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase".Biochem. Mol. Biol. Int.33 (2): 410.PMID 7951059.
Islam MM, Tanaka M, Suzuki H, et al. (1995). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase".Biochem. Mol. Biol. Int.33 (4): 815.PMID 7981668.
Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase".Biochem. Mol. Biol. Int.32 (5):797–805.PMID 8069229.
Hughes GJ, Frutiger S, Paquet N, et al. (1994). "Human liver protein map: update 1993".Electrophoresis.14 (11):1216–22.doi:10.1002/elps.11501401181.PMID 8313870.S2CID 33424554.
Hillier LD, Lennon G, Becker M, et al. (1997)."Generation and analysis of 280,000 human expressed sequence tags".Genome Res.6 (9):807–28.doi:10.1101/gr.6.9.807.PMID 8889549.
Valnot I, Kassis J, Chretien D, et al. (1999). "A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency".Hum. Genet.104 (6):460–6.doi:10.1007/s004390050988.PMID 10453733.S2CID 30584267.
Hu WH, Hausmann ON, Yan MS, et al. (2002). "Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP)".J. Neurochem.81 (1):36–45.doi:10.1046/j.1471-4159.2002.00788.x.PMID 12067236.S2CID 38794348.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005)."Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes".Biochem. J.383 (Pt 2):237–48.doi:10.1042/BJ20040647.PMC 1134064.PMID 15242332.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection".Free Radic. Biol. Med.37 (12):2072–81.doi:10.1016/j.freeradbiomed.2004.09.011.PMID 15544925.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437 (7062):1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID 16189514.S2CID 4427026.
Kulawiec M, Arnouk H, Desouki MM, et al. (2007). "Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer".Cancer Biol. Ther.5 (8):967–75.doi:10.4161/cbt.5.8.2880.PMID 16775426.S2CID 84608368.
Ewing RM, Chu P, Elisma F, et al. (2007)."Large-scale mapping of human protein-protein interactions by mass spectrometry".Mol. Syst. Biol.3 (1): 89.doi:10.1038/msb4100134.PMC 1847948.PMID 17353931.

v t e PDB gallery
1be3: CYTOCHROME BC1 COMPLEX FROM BOVINE 1bgy: CYTOCHROME BC1 COMPLEX FROM BOVINE 1l0l: structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone 1l0n: native structure of bovine mitochondrial cytochrome bc1 complex 1ntk: Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1 1ntm: Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom 1ntz: Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone 1nu1: Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) 1pp9: Bovine cytochrome bc1 complex with stigmatellin bound 1ppj: Bovine cytochrome bc1 complex with stigmatellin and antimycin 1qcr: CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY 1sqq: Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS) 1sqv: Crystal Structure Analysis of Bovine Bc1 with UHDBT 1sqx: Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A 2a06: Bovine cytochrome bc1 complex with stigmatellin bound 2fyu: Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor

PDB gallery

1be3: CYTOCHROME BC1 COMPLEX FROM BOVINE
1bgy: CYTOCHROME BC1 COMPLEX FROM BOVINE
1l0l: structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone
1l0n: native structure of bovine mitochondrial cytochrome bc1 complex
1ntk: Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1
1ntm: Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom
1ntz: Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone
1nu1: Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO)
1pp9: Bovine cytochrome bc1 complex with stigmatellin bound
1ppj: Bovine cytochrome bc1 complex with stigmatellin and antimycin
1qcr: CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY
1sqq: Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS)
1sqv: Crystal Structure Analysis of Bovine Bc1 with UHDBT
1sqx: Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A
2a06: Bovine cytochrome bc1 complex with stigmatellin bound
2fyu: Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor