Function

Interactions

• Baculoviral IAP repeat-containing protein 3,^[7]
• NEDD4,^[8][9]
• PJA1,^[10]
• PJA2,^[10] and
• UBE3A.^[8][9]

References

Further reading

• Rolfe M, Beer-Romero P, Glass S, Eckstein J, Berdo I, Theodoras A, Pagano M, Draetta G (Apr 1995)."Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)".Proceedings of the National Academy of Sciences of the United States of America.92 (8):3264–8.Bibcode:1995PNAS...92.3264R.doi:10.1073/pnas.92.8.3264.PMC 42146.PMID 7724550.
• Scheffner M, Huibregtse JM, Howley PM (Sep 1994)."Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53".Proceedings of the National Academy of Sciences of the United States of America.91 (19):8797–801.Bibcode:1994PNAS...91.8797S.doi:10.1073/pnas.91.19.8797.PMC 44693.PMID 8090726.
• Hatakeyama S, Jensen JP, Weissman AM (Jun 1997)."Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases".The Journal of Biological Chemistry.272 (24):15085–92.doi:10.1074/jbc.272.24.15085.PMID 9182527.
• Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes".Genes to Cells.3 (11):751–63.doi:10.1046/j.1365-2443.1998.00227.x.PMID 9990509.S2CID 1653536.
• Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, Ciechanover A (May 1999)."Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha".The Journal of Biological Chemistry.274 (21):14823–30.doi:10.1074/jbc.274.21.14823.PMID 10329681.
• Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC (Oct 1999). "The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase".Science.286 (5438):309–12.doi:10.1126/science.286.5438.309.PMID 10514377.
• Tongaonkar P, Chen L, Lambertson D, Ko B, Madura K (Jul 2000)."Evidence for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome".Molecular and Cellular Biology.20 (13):4691–8.doi:10.1128/MCB.20.13.4691-4698.2000.PMC 85887.PMID 10848595.
• Strack P, Caligiuri M, Pelletier M, Boisclair M, Theodoras A, Beer-Romero P, Glass S, Parsons T, Copeland RA, Auger KR, Benfield P, Brizuela L, Rolfe M (Jul 2000). "SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4".Oncogene.19 (31):3529–36.doi:10.1038/sj.onc.1203647.PMID 10918611.S2CID 24267499.
• Fang S, Ferrone M, Yang C, Jensen JP, Tiwari S, Weissman AM (Dec 2001)."The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum".Proceedings of the National Academy of Sciences of the United States of America.98 (25):14422–7.Bibcode:2001PNAS...9814422F.doi:10.1073/pnas.251401598.PMC 64697.PMID 11724934.
• Yu P, Chen Y, Tagle DA, Cai T (Jun 2002)."PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain".Genomics.79 (6):869–74.doi:10.1006/geno.2002.6770.PMID 12036302.
• Xia Y, Pao GM, Chen HW, Verma IM, Hunter T (Feb 2003)."Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein".The Journal of Biological Chemistry.278 (7):5255–63.doi:10.1074/jbc.M204591200.PMID 12431996.
• Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (Jun 2003)."The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity".The Journal of Biological Chemistry.278 (24):21930–7.doi:10.1074/jbc.M301157200.PMID 12670957.
• Xu L, Yang L, Moitra PK, Hashimoto K, Rallabhandi P, Kaul S, Meroni G, Jensen JP, Weissman AM, D'Arpa P (Aug 2003). "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta".Experimental Cell Research.288 (1):84–93.doi:10.1016/S0014-4827(03)00187-3.PMID 12878161.
• Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A (Oct 2003)."The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase".British Journal of Cancer.89 (8):1538–44.doi:10.1038/sj.bjc.6601301.PMC 2394340.PMID 14562029.
• Shimura H, Schwartz D, Gygi SP, Kosik KS (Feb 2004)."CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival".The Journal of Biological Chemistry.279 (6):4869–76.doi:10.1074/jbc.M305838200.PMID 14612456.
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region".Genomics.83 (1):153–67.doi:10.1016/S0888-7543(03)00235-0.PMID 14667819.
• Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT (Mar 2004). "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair".Journal of Molecular Biology.337 (1):157–65.doi:10.1016/j.jmb.2004.01.031.PMID 15001359.