US 49 highlighted in red | ||||||||||
| Route information | ||||||||||
| Length | 516 mi[citation needed] (830 km) | |||||||||
| Existed | 1926[citation needed]–present | |||||||||
| Southern section | ||||||||||
| South end | ||||||||||
| Major intersections | ||||||||||
| North end | ||||||||||
| Northern section | ||||||||||
| South end | ||||||||||
| Major intersections | ||||||||||
| North end | ||||||||||
| Location | ||||||||||
| Country | United States | |||||||||
| States | Mississippi,Arkansas | |||||||||
| Counties | MS:Harrison,Stone,Forrest,Covington,Simpson,Rankin,Hinds,Madison,Yazoo;Tallahatchie,Coahoma AR:Phillips,Monroe,Woodruff,Cross,Poinsett,Craighead,Greene,Clay | |||||||||
| Highway system | ||||||||||
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U.S. Route 49 (US 49) is a north–southUnited States highway. The highway's northern terminus is inPiggott, Arkansas, at an intersection withU.S. Route 62 (US 62). Its southern terminus is inGulfport, Mississippi, at an intersection withUS 90. US 49 is approximately 516 miles (830 km) in length.
It was at the junction of US 49 andU.S. Route 61 thatblues singerRobert Johnson is said to have sold his soul to theDevil. The highway is also the subject of songs by Big Joe Williams andHowlin' Wolf (Chester Arthur Burnett).
| mi[1] | km | |
|---|---|---|
| MS | 334 | 538 |
| AR | 182 | 113 |
| Total | 516 | 321 |
US 49 has historically been one of the most important highways in Mississippi. It was the state's first highway to see a significant rural segment four-laned.[2] Today, it is the only four-laned route directly connectingJackson, the state's capital and largest city, to theMississippi Gulf Coast.[3] Some urban segments along this portion of the route maintain three or more traffic lanes in each direction. US 49 serves as a primary hurricane evacuation route for Gulf Coast residents.[4]

US 49 begins near the Port ofGulfport, Mississippi at a junction withUS 90. It provides a major connection between the port, casinos, beaches and downtown withI-10 (exits 34A-B), where it has its first major junction being a full servicecloverleaf interchange on the city's north end. The crossing of these two roads is officially recognized by the state of Mississippi as the Castilgia Interchange.[5] North of I-10, US 49 passes through suburban areas and entersDe Soto National Forest. Various state highway interchanges and junctions are encountered before the route passes nearCamp Shelby, then through an interchange withUS 98 just south ofHattiesburg. At this point, travelers have an option of continuing on US 49 through Hattiesburg or using theI-59/US 98 bypass which reconnects with US 49 in the northern part of the city. Continuing on US 49 brings one to a cloverleaf interchange atUS 11, one of very few in the South to lack merging lanes between loop ramps, thus exacerbating theweaving patterns which plague many cloverleaf interchanges.
US 49 passes Hattiesburg's primary medical facility,Forrest General Hospital, and the campus of theUniversity of Southern Mississippi before arriving at another, more standard cloverleaf interchange with I-59. Those who used the aforementioned bypass, wishing to reconnect with US 49 North to the state capital, must use exit 67B. It is also at I-59, whereMississippi Highway 42 (MS 42) runs with US 49 for a short distance as suburban development is soon encountered as the road returns to rural environs. Eventually, MS 42 departs from the four-laned highway and branches off to the west toward smaller towns, starting withSumrall. Interchanges between Hattiesburg and Jackson provide access to various state highways, and one at Collins provides access toUS 84.

At Jackson, US 49 upgrades toInterstate Highway standards before joiningI-20 using a two-lane flyover. About a mile later, I-20/US 49 merges withI-55 at astack interchange. I-20/I-55/US 49 crosses the Pearl River into Hinds County and bypasses Downtown Jackson, where I-55 departs to the south. US 49/I-20 continue west until US 49 ends its run with I-20 and joinsI-220 before turning northwest toYazoo City. A split in the highway, rare in theU.S. Highway System, begins here; both routes head into the Mississippi Delta,US 49W serving the towns ofBelzoni andIndianola, where it junctions withUS 82 and its four-lane segment ends, while two-lanedUS 49E servesTchula before encountering US 82 atGreenwood. Both routes continue north from US 82 and are linked again atTutwiler. Continuing northwest, the highway passes through an interchange withUS 61 as it entersClarksdale. It is at Clarksdale that US 49 encounters "The Crossroads", the legendary junction with State Street (an old alignment of US 61) where the great blues musicianRobert Johnson is reputed to have sold his soul to the devil.[6]
From Clarksdale, US 49 continues north and crosses theMississippi River using theHelena Bridge where it enters Arkansas near the town ofHelena.


In May 2005 portions of extant US 49E were renamed the "Emmett Till Memorial Highway".[7]
The Mississippi section of US 49 and the routes of US 49E and US 49W are defined at Mississippi Code Annotated § 65-3-3.
US 49 enters Arkansas nearHelena-West Helena inPhillips County.US 49 Business runs around the north part of the city, with the main route meetingAR 242 in the southern portion. US 49 continues west to Walnut Corner where the route meetsAR 1 (and brieflyAR 316). The US 49/AR 1 concurrency ends inMarvell and US 49 entersMonroe County.
Upon entering Monroe County, US 49 turns north to begin a concurrency withAR 39. US 49 also crossesUS 79 before meetingUS 70 nearBrinkley. The route crossesInterstate 40 north of Brinkley prior to enteringWoodruff County. US 49 runs northeast through rural Woodruff County, not crossing of concurring with any important routes before crossing intoCross County.
The route meetsUS 64 inFair Oaks and meetsAR 42 in southernHickory Ridge. It then entersPoinsett County, concurring withAR 214 fromFisher untilWaldenburg. The route crossesAR 14 in Waldenburg.
US 49 runs along southJonesboro, withUS 49 Business formerly running into town. US 49 concurs withUS 63 until again joining AR 1. The two routes angle north through downtown Jonesboro, crossingUS 63 Business and passing byASU Stadium before leaving town. US 49/AR 1 pass aroundBrookland, withUS 49 Business serving the community.
EnteringGreene County, US 49/AR 1 intersectsUS 412 and briefly meetsAR 358 before enteringParagould. The routes crossUS 412B nearKirk Field in Paragould, also meetingAR 135 north of town.US 49B also rejoins US 49/AR 1 north of Paragould.
Continuing northeast through rural Greene County, US 49/AR 1 meetAR 34 inMarmaduke andAR 90 inRector. The route turns north toPiggott at Hargrave Corner, terminating atUS 62/AR 139. The Arkansas portion of US 49 is mainly two-lane undivided.
One of the original US highways, US 49 was extended north fromClarksdale, Mississippi toUS 70 inBrinkley, Arkansas viaU.S. Route 61 andHighway 6 in 1963.[8] US 49 was again extended north in 1978, replacingHighway 39 between Brinkley andJonesboro.[9]: 269–270 Highway 1 between Jonesboro andPiggott was redesignated as US 49 in 1979.[9]: 66
It is notable that for several years during the 1930s, a second split route existed on US 49 in South Mississippi, similar to but shorter than the split that still exists in the Delta region.[10] Between Brooklyn and Hattiesburg, travelers had the option of a 24-mile-long (39 km) direct route via US 49W, or a somewhat shorter but broken route on US 49E, serving theForrest County Agricultural High School and the small community ofMcLaurin, Mississippi.
| State | County | Location | mi[11][12] | km | Exit | Destinations | Notes |
|---|---|---|---|---|---|---|---|
| Mississippi | Harrison | Gulfport | 0.00 | 0.00 | Southern terminus | ||
| 4.4– 4.9 | 7.1– 7.9 | Exits 34A-B on I-10 | |||||
| 9.4 | 15.1 | ||||||
| | 20.0– 20.6 | 32.2– 33.2 | Interchange | ||||
| Stone | Wiggins, Stone County | 32.9 | 52.9 | ||||
| 34.2– 34.6 | 55.0– 55.7 | Interchange | |||||
| 36.7 | 59.1 | ||||||
| Forrest | | 41.6 | 66.9 | ||||
| | 54.6 | 87.9 | S Lake Drive –Paul B. Johnson State Park | Access road into park | |||
| Hattiesburg | 62.3– 62.8 | 100.3– 101.1 | Interchange | ||||
| 65.1 | 104.8 | Edwards Street (MS 969 north) | |||||
| 67.5– 67.9 | 108.6– 109.3 | Interchange | |||||
| 69.1 | 111.2 | ||||||
| 70.7 | 113.8 | Old Highway 42 -Petal | FormerMS 42 east | ||||
| 71.6– 72.0 | 115.2– 115.9 | Southern end of MS 42 concurrency; exit 67 on I-59 | |||||
| | 77.5 | 124.7 | Northern end of MS 42 concurrency | ||||
| Covington | | 84.2 | 135.5 | ||||
| Seminary | 88.9 | 143.1 | |||||
| 89.1 | 143.4 | ||||||
| Collins | 95.1– 95.5 | 153.0– 153.7 | Interchange | ||||
| 96.4– 96.7 | 155.1– 155.6 | Interchange | |||||
| | 104.2 | 167.7 | |||||
| Mount Olive | 104.7 | 168.5 | |||||
| 106.6 | 171.6 | ||||||
| Simpson | Magee | 113.4 | 182.5 | ||||
| 114.1 | 183.6 | Southern end of MS 28 concurrency | |||||
| 114.2 | 183.8 | Southern end of MS 541 concurrency | |||||
| 114.6 | 184.4 | Northern end of MS 28/MS 541 concurrency | |||||
| 117.0 | 188.3 | Interchange | |||||
| | 119.3 | 192.0 | |||||
| Mendenhall | 123.8 | 199.2 | |||||
| 124.1 | 199.7 | ||||||
| 126.1– 126.4 | 202.9– 203.4 | Interchange | |||||
| | 134.2 | 216.0 | |||||
| Rankin | Florence | 145.5 | 234.2 | ||||
| Richland | 151.8 | 244.3 | |||||
| 152.6– 152.9 | 245.6– 246.1 | East Frontage Road | Interchange; northbound exit and entrance | ||||
| West Frontage Road | Interchange; southbound exit and entrance | ||||||
| Richland–Pearl line | 153.8 | 247.5 | 47 | Southern end of I-20/I-55 concurrency; exit 94 on I-55 | |||
| Hinds | Jackson | 154.3 | 248.3 | 45B | Southbound exit is exit 45 | ||
| 154.6 | 248.8 | 45A | Gallatin Street | Southbound exit is exit 45 | |||
| 155.3 | 249.9 | 44 | Northern end of I-55 concurrency | ||||
| 155.6 | 250.4 | 43 | Terry Road / University Boulevard | Signed as exits 43A (south) and 43B (north) | |||
| 156.4 | 251.7 | 42 | Ellis Avenue | Signed as exits 42A (south) and 42B (north) | |||
| 159.7 | 257.0 | 41 | Northern end of I-20 concurrency; southern terminus of I-220 | ||||
| 160 | 260 | 1 | Signed as exits 1A (east) and 1B (west) | ||||
| 161.3 | 259.6 | 2 | Clinton Boulevard / Capitol Street | Signed as exits 2A (Capitol Street) and 2B (Clinton Blvd.) northbound | |||
| 162.7 | 261.8 | 3 | Industrial Drive | Diamond interchange | |||
| 164.7 | 265.1 | 5 | Signed as exits 5A (Medgar Evers) and 5B (I-220); northern end of I-220 concurrency | ||||
| 167.1– 167.3 | 268.9– 269.2 | Interchange | |||||
| Madison | Flora | 179.0 | 288.1 | ||||
| Yazoo | Bentonia | 186.3 | 299.8 | Eastern terminus of MS 830 | |||
| 187.0 | 300.9 | ||||||
| 187.7 | 302.1 | Western terminus of MS 830 | |||||
| | 200.7 | 323.0 | Southern end of MS 16 concurrency | ||||
| Yazoo City | 201.0 | 323.5 | Northern end of MS 16 concurrency | ||||
| 204.2 | 328.6 | Interchange; US 49 north splits into US 49E and US 49W | |||||
| SeeUS 49E andUS 49W | |||||||
| Tallahatchie | Tutwiler | 0.0 | 0.0 | Southern end of MS 3 concurrency; US 49 south splits into US 49E and US 49W | |||
| 0.4 | 0.64 | Northern end of MS 3 concurrency | |||||
| 0.6 | 0.97 | ||||||
| Coahoma | Clarksdale | 12.5 | 20.1 | Southern end of MS 322 concurrency | |||
| 13.0 | 20.9 | Interchange; northern end of MS 322 concurrency; southern end of US 61/US 278 concurrency | |||||
| 116.3– 117.0 | 187.2– 188.3 | Northern end of US 278 concurrency | |||||
| | 118.0 | 189.9 | |||||
| | 27.3 | 43.9 | Friars Point-Highway 61 / Highway 61-Jonestown –Friars Point,Moon Lake | ProposedMS 316 | |||
| | 31.8 | 51.2 | North end of US 61 overlap; south end of Great River Road overlap | ||||
| | 37.9 | 61.0 | |||||
| Mississippi River | 40.9 0.00 | 65.8 0.00 | Helena Bridge | ||||
| Arkansas | Phillips | Helena-West Helena | 0.99 | 1.59 | |||
| 1.35 | 2.17 | Former AR 49 | |||||
| 3.98 | 6.41 | ||||||
| 6.28 | 10.11 | ||||||
| 6.88 | 11.07 | ||||||
| Walnut Corner | 12.48 | 20.08 | |||||
| Kindall | 15.45 | 24.86 | |||||
| Poplar Grove | 17.58 | 28.29 | |||||
| Marvell | 20.62 | 33.18 | |||||
| 21.52 | 34.63 | ||||||
| | 27.56 | 44.35 | |||||
| | 29.67 | 47.75 | |||||
| Monroe | | 33.56 | 54.01 | ||||
| | 35.60 | 57.29 | |||||
| | 36.70 | 59.06 | |||||
| | 38.67 | 62.23 | |||||
| | 41.30 | 66.47 | |||||
| | 43.55 | 70.09 | |||||
| | 50.67 | 81.55 | |||||
| Brinkley | 51.80 | 83.36 | South end of US 70 overlap | ||||
| 52.55 | 84.57 | ||||||
| 53.39 | 85.92 | Northern end of US 70 concurrency | |||||
| 54.97 | 88.47 | Southern end of US 63 concurrency; exit 216 on I-40 | |||||
| 56.13 | 90.33 | ||||||
| Woodruff | | 62.47 | 100.54 | ||||
| Hunter | 66.28 | 106.67 | |||||
| | 71.61 | 115.25 | |||||
| Penrose | 76.23 | 122.68 | |||||
| Cross | Fair Oaks | 80.26 | 129.17 | Southern end of US 64 concurrency | |||
| 80.28 | 129.20 | Northern end of US 64 concurrency | |||||
| Tilton | 84.88 | 136.60 | |||||
| Hickory Ridge | 90.44 | 145.55 | |||||
| Poinsett | Fisher | 96.67 | 155.58 | ||||
| Waldenburg | 102.74 | 165.34 | |||||
| | 104.9 | 168.8 | |||||
| | 109.34 | 175.97 | |||||
| Poinsett–Craighead county line | | 113.42 | 182.53 | ||||
| Craighead | Jonesboro | 120.50 | 193.93 | Southern end of US 78/AR 226 concurrency | |||
| 122.4 | 197.0 | Northern end of AR 226 concurrency | |||||
| 125.53 | 202.02 | 45 | Northern end of US 63 concurrency; southern end of I-555 concurrency | ||||
| 43.4 | 69.8 | 44 | |||||
| 128.40 | 206.64 | 42 | Northern end of I-555/US 78 concurrency; southern end of AR 1 concurrency | ||||
| 129.53 | 208.46 | ||||||
| 131.74 | 212.01 | Southern terminus of AR 91 | |||||
| 132.31 | 212.93 | Southern end of AR 351 concurrency | |||||
| 132.75 | 213.64 | Northern end of AR 351 concurrency | |||||
| | 136.7 | 220.0 | |||||
| | 140.60 | 226.27 | |||||
| Greene | Paragould | 144.65 | 232.79 | ||||
| 146.85 | 236.33 | ||||||
| 147.34 | 237.12 | ||||||
| 147.87 | 237.97 | ||||||
| 149.71 | 240.93 | ||||||
| 149.97 | 241.35 | ||||||
| 151.13 | 243.22 | ||||||
| 151.88 | 244.43 | ||||||
| Marmaduke | 161.44 | 259.81 | |||||
| Clay | Rector | 168.86 | 271.75 | Southern end of AR 90 concurrency | |||
| 169.37 | 272.57 | ||||||
| Hargrave Corner | 172.33 | 277.34 | Northern end of AR 90 concurrency | ||||
| Piggott | 182.33 | 293.43 | Northern terminus; northern end of AR 1 concurrency | ||||
1.000 mi = 1.609 km; 1.000 km = 0.621 mi
| |||||||
| Location | Yazoo City-Tutwiler |
|---|---|
| Length | 85.862 mi[13] (138.181 km) |
U.S. Route 49E (US 49E) is an 85.86-mile-long (138.18 km)U.S. Highway in the Delta region ofMississippi. It travels throughYazoo,Holmes,Leflore, andTallahatchie counties.
| Location | Yazoo City-Tutwiler |
|---|---|
| Length | 81.894 mi[13] (131.796 km) |
U.S. Route 49W (US 49W) is an 81.89-mile-long (131.79 km)U.S. Highway in the Delta Region ofMississippi, passing throughYazoo,Humphreys,Sunflower, andTallahatchie counties.
| Location | Stone,Covington,Simpson,Rankin,Yazoo,Humphreys,Sunflower, andCoahoma counties |
|---|---|
| Length | 58.073 mi (93.459 km) |
| Existed | 2006–present |
Mississippi Highway 149 (MS 149) is astate highway inMississippi. The route designation is given to six former segments ofU.S. Route 49 (US 49), and two former sections ofUS 49W, within the state that have been bypassed. The sections run throughWiggins,Mount Olive, betweenMagee andSanatorium, betweenMendenhall andBraxton, inRichland, Mississippi, betweenYazoo City andSilver City,Inverness, andClarksdale. The total length of the eight sections of MS 149 is 58.073 miles (93.459 km).
| Location | Craighead andLawrence counties |
|---|---|
| Length | 6.89 mi (11.09 km) |
| Existed | November 23, 1966–present |
Arkansas Highway 349 is a designation for twostate highways inNortheast Arkansas. One route of 4.45 miles (7.16 km) begins atHighway 226 and runs north toHighway 18/Highway 91. A second route of 2.44 miles (3.93 km) begins atHighway 230 and runs north toHighway 228. Both routes are maintained by theArkansas Department of Transportation (ArDOT).