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| Formula | C17H13ClN6O |
| Molar mass | 352.78 g·mol−1 |
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U-90042 is asedative andhypnotic drug used in scientific research. It has similar effects to sedative-hypnoticbenzodiazepine drugs, but is structurally distinct and so is classed as anonbenzodiazepine hypnotic.
U-90042 is aGABAA agonist acting primarily at the α1, α3 and α6 subtypes, with aKi of 7.8nM at α1, 9.5nM at α3 and 11.0nM at α6. It producessedation andataxia and prolongs sleeping time in mice, rats and monkeys, but does not produceamnesia and blocks the amnestic effect ofdiazepam, reflecting its different subtype affinity compared to benzodiazepine drugs.[1] It was developed by a team atNovo Nordisk in the 1980s.[2]
