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Tunlametinib

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Tunlametinib
Clinical data
Other namesHL-085
ATC code
  • None
Legal status
Legal status
  • Rx in China
Identifiers
  • 4-Fluoro-5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,3-benzothiazole-6-carboxamide
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC16H12F2IN3O3S
Molar mass491.25 g·mol−1

Tunlametinib is a pharmaceutical drug for the treatment of cancer. It is an inhbitor ofmitogen-activated protein kinase kinase.[1]

In China, tunlametinib was approved in 2024 for the treatment of patients withNRAS-mutated advancedmelanoma who were previously treated with aPD-1/PD-L1 targeting agent.[2][3]

It is also being studied for use in combination withvemurafenib in patients with advanced BRAF V600-mutant solid tumors.[4]

References

[edit]
  1. ^"Tunlametinib".NCI Drug Dictionary.National Cancer Institute.
  2. ^"Tunlametinib Wins Approval in China for NRAS+ Advanced Melanoma After PD-1/PD-L1 Therapy". 18 March 2024.
  3. ^Keam SJ (2024)."Tunlametinib: First Approval".Drugs.84 (8):1005–1010.doi:10.1007/s40265-024-02072-x.PMID 39034326.
  4. ^Shi Y, Han X, Zhao Q, Zheng Y, Chen J, Yu X, et al. (2024)."Tunlametinib (HL-085) plus vemurafenib in patients with advanced BRAF V600-mutant solid tumors: An open-label, single-arm, multicenter, phase I study".Experimental Hematology & Oncology.13 (1): 60.doi:10.1186/s40164-024-00528-0.PMC 11167782.PMID 38867257.
CImonoclonal antibodies ("-mab")
Receptor tyrosine kinase
Others for solid tumors
Leukemia/lymphoma
Other
Tyrosine kinase inhibitors ("-nib")
Receptor tyrosine kinase
Non-receptor
Other
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