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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Inhaled, oral, transdermal patch |
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| ECHA InfoCard | 100.168.691 |
| Chemical and physical data | |
| Formula | C12H18ClNO |
| Molar mass | 227.73 g·mol−1 |
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Tulobuterol (INN) is a long-actingbeta2-adrenergic receptor agonist, marketed in Japan as atransdermal patch under the nameHokunalin tape (ホクナリンテープ).[1]
Currently, it is only legal in 7 countries: Japan, Germany, China, South Korea, Bangladesh, Pakistan, and Venezuela. It is available in India also.
The oxidation of 2'-chloroacetophenone (1) withselenium dioxide gives o-chlorophenylglyoxal (2). Condensation withtert-butylamine gives theimine (3). Reduction withsodium borohydride completes the synthesis of tulobuterol.[2]
