Inenzymology, atropinone reductase I (EC1.1.1.206) is anenzyme thatcatalyzes thechemical reaction

tropine + NADP⁺${\displaystyle \rightleftharpoons }$ tropinone + NADPH + H⁺

Thus, the twosubstrates of this enzyme aretropine andNADP⁺, whereas its 3products aretropinone,NADPH, andH⁺.

This enzyme belongs to the family ofoxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. Thesystematic name of this enzyme class istropine:NADP⁺ 3alpha-oxidoreductase. Other names in common use includetropine dehydrogenase,tropinone reductase (ambiguous), andTR-I. This enzyme participates in alkaloid biosynthesis ii.

• Koelen KJ; Gross, GG (1982). "Partial purification and properties of tropine dehydrogenase from root cultures ofDatura stramonium".Planta Med.44 (4):227–230.Bibcode:1982PlMed..44..227K.doi:10.1055/s-2007-971454.PMID 17402126.
• Couladis MM, Friesen JB, Landgrebe ME, Leete E (1991). "Enzymes catalysing the reduction of tropinone to tropine and ψ-tropine isolated from the roots ofDatura innoxia'".Phytochemistry.30 (3):801–805.Bibcode:1991PChem..30..801C.doi:10.1016/0031-9422(91)85255-X.
• Nakajima K, Hashimoto T, Yamada Y (1993)."Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor".Proc. Natl. Acad. Sci. U.S.A.90 (20):9591–5.Bibcode:1993PNAS...90.9591N.doi:10.1073/pnas.90.20.9591.PMC 47615.PMID 8415746.
• Drager B (2006). "Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism".Phytochemistry.67 (4):327–37.Bibcode:2006PChem..67..327D.doi:10.1016/j.phytochem.2005.12.001.PMID 16426652.

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