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| Names | |||
|---|---|---|---|
| Preferred IUPAC name (1R,3r,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol | |||
| Other names α-Tropine; Tropanol | |||
| Identifiers | |||
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3D model (JSmol) | |||
| ChemSpider |
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| ECHA InfoCard | 100.003.986 | ||
| MeSH | Tropine | ||
| UNII | |||
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| Properties | |||
| C8H15NO | |||
| Molar mass | 141.214 g·mol−1 | ||
| Appearance | Whitehygroscopic crystalline powder[1][2][3] or plates | ||
| Odor | Amine-like[2] | ||
| Density | 1.045 g/cm3 at 25 °C[2] 1.016 g/cm3 at 100 °C | ||
| Melting point | 64 °C (147 °F; 337 K) | ||
| Boiling point | 233 °C (451 °F; 506 K) | ||
| Solubility | Very soluble in water,diethyl ether,ethanol[4] | ||
| Hazards | |||
| Occupational safety and health (OHS/OSH): | |||
Main hazards | Toxic | ||
| GHS labelling: | |||
  | |||
| Danger | |||
| H301,H302,H312,H332 | |||
| P261,P264,P270,P271,P280,P301+P316,P301+P317,P302+P352,P304+P340,P317,P321,P330,P362+P364,P405,P501 | |||
| Lethal dose or concentration (LD, LC): | |||
LD50 (median dose) | |||
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |||
Tropine is a derivative oftropane containing a hydroxyl group at the third carbon. It is also called 3-tropanol.[4] It is a poisonous whitehygroscopic crystalline powder.[3] It is aheterocyclicalcohol and anamine.[3]
Tropine is acentral building block of many chemicals active in the nervous system, includingtropane alkaloids. Some of these compounds, such aslong-acting muscarinic antagonists are used as medicines because of these effects.[5]
Tropine is a natural product found in the plants of deadly nightshade (Atropa belladonna) and devil's trumpet (Datura stramonium).[1]
It can be prepared by hydrolysis ofatropine[6] or othersolanaceousalkaloids.[3]
