 | |
| Clinical data | |
|---|---|
| Trade names | Flonase Nighttime Allergy Relief, Actidil, others |
| AHFS/Drugs.com | Monograph |
| Pregnancy category |
|
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | Oral: 4% |
| Protein binding | 90% |
| Metabolism | Hepatic (CYP2D6) |
| Eliminationhalf-life | 4–6 hours |
| Excretion | Renal |
| Identifiers | |
| |
| CAS Number |
|
| PubChemCID | |
| IUPHAR/BPS | |
| DrugBank |
|
| ChemSpider |
|
| UNII | |
| KEGG |
|
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.006.934 |
| Chemical and physical data | |
| Formula | C19H22N2 |
| Molar mass | 278.399 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 60 °C (140 °F) |
| Solubility in water | 500 mg/mL (20 °C) |
| |
| |
 N Y (what is this?) (verify) | |
Triprolidine is anover-the-counterantihistamine withanticholinergic properties.[1] It is used to combat the symptoms associated withallergies and is sometimes combined with othercold medications designed to provide general relief forflu-like symptoms.[2] As with many antihistamines, the most commonside effect is drowsiness.[1]
Triprolidine was patented in 1948 and came into medical use in 1953,[3] and has mostly been replaced in popular medications by other antihistamines includingdiphenhydramine,promethazine,chlorpheniramine, as well as bysecond-generation antihistamines includingloratadine andfexofenadine. Triprolidine remains an ingredient in the cold medicineActifed in many territories.[citation needed]