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Tribenoside

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Tribenoside
Clinical data
Other names(3R,4R,5R)-4-(Benzyloxy)-5-[1,2-bis(benzyloxy)ethyl]-2-ethoxyoxolan-3-ol
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • Ethyl 3,5,6-tri-O-benzyl-D-glucofuranoside (TBGF)
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.030.612Edit this at Wikidata
Chemical and physical data
FormulaC29H34O6
Molar mass478.585 g·mol−1
3D model (JSmol)
  • CCOC1[C@@H]([C@H]([C@H](O1)[C@@H](COCc2ccccc2)OCc3ccccc3)OCc4ccccc4)O
  • InChI=1S/C29H34O6/c1-2-32-29-26(30)28(34-20-24-16-10-5-11-17-24)27(35-29)25(33-19-23-14-8-4-9-15-23)21-31-18-22-12-6-3-7-13-22/h3-17,25-30H,2,18-21H2,1H3/t25-,26-,27-,28-,29?/m1/s1 ☒N
  • Key:ULLNJSBQMBKOJH-VIVFLBMVSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Tribenoside (Glyvenol) is avasoprotective drug used to treathemorrhoids.[1] It has mildanti-inflammatory,analgesic, andwound healing properties.[2] Tribenoside stimulateslaminin α5 production andlaminin-332 deposition to help repair thebasement membrane during the wound healing process.[3] It is a mixture of the α- and β-anomers.[citation needed]

Tribenoside has been shown to inducedrug hypersensitivity syndrome in association withCMV reactivation.[4]

References

[edit]
  1. ^Lorenc Z, Gökçe Ö (2016)."Tribenoside and lidocaine in the local treatment of hemorrhoids: an overview of clinical evidence".Eur Rev Med Pharmacol Sci.20 (12):2742–51.PMID 27383331.
  2. ^Jaques R (1977)."The pharmacological activity of tribenoside".Pharmacology.15 (5):445–60.doi:10.1159/000136721.PMID 578928.
  3. ^Kikkawa Y, Takaki S, Matsuda Y, Okabe K, Taniguchi M, Oomachi K, Samejima T, Katagiri F, Hozumi K, Nomizu M (2010)."The influence of Tribenoside on expression and deposition of epidermal laminins in HaCaT cells".Biol Pharm Bull.33 (2):307–10.doi:10.1248/bpb.33.307.PMID 20118558.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^Hashizume H, Takigawa M (2005)."Drug-induced hypersensitivity syndrome associated with cytomegalovirus reactivation: immunological characterization of pathogenic T cells".Acta Derm. Venereol.85 (1):47–50.doi:10.1080/00015550410024094.PMID 15848991.
Antihemorrhoidals for topical use
corticosteroids
local anesthetics
other
Antivaricose therapy
heparins orheparinoids for topical use
sclerosing agents for local injection
other
Capillary stabilising agents
bioflavonoids
other


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