Anabolic-androgenic steroid (AAS) users report significant psychological changes. AAS-induced fluctuations intestosterone, affect the brain's structure and function, potentially leading to mood disorders and aggressive behavior.[8] Trenbolone enanthate users have reported significant psychological changes, including increased aggression, mood instability, and impaired social interactions.[9] Prolonged use of AAS may also lead to psychological dependence, with approximately 1/3 of users experiencing withdrawal symptoms upon cessation.[10]
Anabolic-androgenic steroids impact malereproductive health. Their misuse can lead to a condition known as anabolic steroid-induced hypogonadism (ASIH), where natural testosterone production is suppressed. The decreased testosterone production leads to decreased sperm production and can cause prolongedinfertility even after stopping use.[11] Chronic AAS use increases the risk of infertility due to its impact on hormonal balance, and some effects such as gynecomastia may not be reversible.[12]
Trenbolone enanthate can include severalandrogenic side effects such as increased body hair growth,acne, and potential baldness in predisposed individuals.[7][13]
Gynecomastia is a condition that enlarges the breast tissue in males which is often produced as a side effect from the use of AAS.[10] AAS can disrupt the normal balance ofestrogen andtestosterone in the body due to the increase in testosterone, which can be aromatized into estrogen. Elevated levels of estrogen in males can be linked to both weight gain and gynecomastia.[14] While Trenbolone enanthate is known for notaromatizing into estrogen,[15] trenbolone exhibits highprogestogenic activity which is one of three natural developments of breast tissue in males, also leading to gynecomastia.[16][12]
Trenbolone enanthate is renowned for its capacity to promote significant muscle growth and strength gain. Itsanabolic effects facilitate increasedprotein synthesis and hydrogen retention in muscle tissue.[13] Trenbolone enanthate is also notable in the field of strength gain, with many users reporting marked improvements in their lifting capabilities in part due to the AAS' ability to increase red blood cell count and improve oxygenation ofmuscle tissue along with the increase in testosterone.[17] The compound is also often employed for its fat-burning properties.[18] It enhances themetabolic rate and promotes the conversion of fat into energy,[19] contributing to leaner muscle development duringcutting cycles in body building.[18]
Trenbolone enanthate is a potential treatment for muscle and bone loss without adverse effects commonly associated with testosterone, such asprostate growth or polycythemia.[20] Trenbolone enanthate was hypothesized to offer benefits similar to selectiveandrogen receptor modulators(SARMs) due to its inability to convert into more potentandrogens in specific tissues.[20]
In the veterinary field, Trenbolone acetate has a history of use for increasing muscle mass inlivestock. Trenbolone enanthate however has never been approved for veterinary use.The application of Trenbolone acetate is aimed at improving the lean muscle yield in animals prior to slaughter, enhancing the quality of meat production.[21]
Trenbolone was first synthesized in 1963 byL. Velluz and his co-workers, it was originally developed for veterinary use to improve muscle mass and feed efficiency in cattle;[22] however, trenbolone's potent anabolic and androgenic properties soon caught the attention of bodybuilders and athletes. The drug, however, has never been approved for human use, which has legal implications.[23]
Trenbolone enanthate has never had regulatory approval for human use from any single health agency. It is commonly considered acontrolled substance and use is generally illegal. For example, in the United States, theDrug Enforcement Administration (DEA) considers trenboloneestersSchedule III controlled substances similar to the likes of Australia wherein possession of trenboloneesters is a criminal offence.[24][25] However, this compound is considered aclass C drug with no penalty for personal use or possession in the United Kingdom or Canada.[26] Sporting organizations, including theWorld Anti Doping Agency (WADA), closely monitor the use of such substances, especially in competitive events like theOlympics.[27]
^Piatkowski TM, Neumann DL, Dunn M (September 2023). "'My mind pretty much went to mush': A qualitative exploration of trenbolone in the performance and image enhancing drug community".Drug and Alcohol Review.42 (6):1566–1576.doi:10.1111/dar.13656.hdl:10072/422455.PMID36992616.
^Bauer ER, Daxenberger A, Petri T, Sauerwein H, Meyer HH (December 2000). "Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor".APMIS.108 (12):838–846.doi:10.1111/j.1600-0463.2000.tb00007.x.PMID11252818.S2CID22776408.
^abDonner DG, Beck BR, Bulmer AC, Lam AK, Du Toit EF (February 2015). "Improvements in body composition, cardiometabolic risk factors and insulin sensitivity with trenbolone in normogonadic rats".Steroids.94:60–69.doi:10.1016/j.steroids.2014.12.017.hdl:10072/156381.PMID25554582.
Yarrow JF, McCoy SC, Borst SE (2010). "Tissue selectivity and potential clinical applications of trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity".Steroids.75 (6):377–89.doi:10.1016/j.steroids.2010.01.019.PMID20138077.S2CID205253265.
