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| Names | |
|---|---|
| IUPAC name [(3aR,8bS)-3,4,8b-Trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl]N-(2-methylphenyl)carbamate | |
| Other names 2-Methylphenserine | |
| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
| ChemSpider | |
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| Properties | |
| C21H25N3O2 | |
| Molar mass | 351.450 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Tolserine (2-methylphenserine) is an inhibitor ofacetylcholinesterase. It has been described as of potential interest for the treatment ofmyasthenia gravis (MG)[1] andAlzheimer's disease.[2]
Tolserine is a substituted derivative ofphenserine.[3] Additionally, certainanalogs of tolserine possess less selectivity between different cholinesterase enzymes.[4]
As an inhibitor of theAChE enzyme, tolserine slows the breakdown ofacetylcholine, a neurotransmitter. Tests have described tolserine as having an averageIC50 value of 8.13 nM and an estimated Ki of 4.69 nM, which represents a more potent inhibition than its parent compound phenserine.[5]