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Tofenacin

From Wikipedia, the free encyclopedia
SNRI antidepressant medication
Pharmaceutical compound
Tofenacin
Clinical data
Trade namesElamol, Tofacine, Tofalin
Other namestofenacin hydrochloride (USANUS)
Routes of
administration
By mouth
ATC code
  • None
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • N-methyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
ECHA InfoCard100.035.746Edit this at Wikidata
Chemical and physical data
FormulaC17H21NO
Molar mass255.361 g·mol−1
3D model (JSmol)
  • O(CCNC)C(c1ccccc1)c2ccccc2C
  • InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)17(19-13-12-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3
  • Key:PNYKGCPSFKLFKA-UHFFFAOYSA-N

Tofenacin is anantidepressantdrug with atricyclic-likestructure which was developed and marketed in theUnited Kingdom andItaly in 1971 and 1981, respectively, by Brocades-Stheeman & Pharmacia (now part ofAstellas Pharma).[1][2][3] It acts as aserotonin-norepinephrine reuptake inhibitor,[4] and based on its close relation toorphenadrine, may also possessanticholinergic andantihistamine properties. Tofenacin is also the majoractive metabolite of orphenadrine and likely plays a role in its beneficial effects againstdepressivesymptoms seen inParkinson's disease patients.[5][6]

See also

[edit]

References

[edit]
  1. ^Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 1041.ISBN 978-3-88763-075-1. Retrieved19 May 2012.
  2. ^Buckingham J (1996).Dictionary of organic compounds: Chemical Abstracts Service registry number index. CRC Press. p. 6074.ISBN 978-0-412-54090-5. Retrieved19 May 2012.
  3. ^Pharmaceutical Manufacturing Encyclopedia (3rd ed.). Elsevier. 2013-01-15. p. 3268.ISBN 978-0-8155-1526-5. Retrieved19 May 2012.
  4. ^van Dijk J, Hartog J, Hillen FC (1 January 1978)."Non-Tricyclic Antidepressants". In Ellis GP, West GB (eds.).Progress in Medicinal Chemistry. Elsevier. p. 284.ISBN 978-0-7204-0655-9. Retrieved19 May 2012.
  5. ^Capstick N, Pudney H (1976). "A comparative trial of orphenadrine and tofenacin in the control of depression and extrapyramidal side-effects associated with fluphenazine decanoate therapy".The Journal of International Medical Research.4 (6):435–440.doi:10.1177/030006057600400610.PMID 800383.S2CID 40083513.
  6. ^Altamura AC, Mauri MC, De Novellis F, Percudani M, Vampini V (November 1989). "Residual neuroleptic-induced parkinsonian symptoms in schizophrenia. A naturalistic study with orphenadrine".Pharmacopsychiatry.22 (6):246–249.doi:10.1055/s-2007-1014608.PMID 2616635.S2CID 39693625.
SSRIsTooltip Selective serotonin reuptake inhibitors
SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors
NRIsTooltip Norepinephrine reuptake inhibitors
NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants
SARIsTooltip Serotonin antagonist and reuptake inhibitors
SMSTooltip Serotonin modulator and stimulators
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TCAsTooltip Tricyclic antidepressants
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DATTooltip Dopamine transporter
(DRIsTooltip Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter
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SERTTooltip Serotonin transporter
(SRIsTooltip Serotonin reuptake inhibitors)
VMATsTooltip Vesicular monoamine transporters
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mAChRsTooltip Muscarinic acetylcholine receptors
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