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| Names | |
|---|---|
| IUPAC name α-Hydro-ω-{[4-oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl}oxy)butanoyl]oxy}poly(oxyethylene) | |
| Other names Tocofersolan; Vitamin E PEG succinate; α-Tocopherol polyethylene glycol succinate (TPGS); Liqui-E | |
| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
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| DrugBank | |
| ECHA InfoCard | 100.123.651 |
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| Properties | |
| (C2H4O)nC33H54O5 | |
| Molar mass | Variable |
| Pharmacology | |
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Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
| Clinical data | |
|---|---|
| Trade names | Vedrop |
| Other names | Tocophersolan (USANUS) |
| AHFS/Drugs.com | UK Drug Information |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.123.651 |
Tocofersolan (INN; also known astocophersolan,tocopherol polyethylene glycol succinate, orTPGS) is a synthetic water-soluble version ofvitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is apolyethylene glycol (PEG) derivative ofα-tocopherolsuccinate. The addition of PEG enables water solubility.
Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease.[3]On 24 July 2009 theEuropean Medicines Agency approved tocofersolan under the trade nameVedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestivemalabsorption inpaediatric patients withcongenital or hereditary chroniccholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).[4]
Tocofersolan is also used in cosmetics and pharmaceuticals as anantioxidant.[5]
