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| Clinical data | |
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| Trade names | Vagistat-1, 1-Day |
| Other names | Thioconazole |
| AHFS/Drugs.com | Monograph |
| Routes of administration | Topical |
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| ECHA InfoCard | 100.059.958 |
| Chemical and physical data | |
| Formula | C16H13Cl3N2OS |
| Molar mass | 387.70 g·mol−1 |
| Chirality | Racemic mixture |
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Tioconazole is anantifungal medication of theimidazole class used to treat infections caused by a fungus or yeast. It is marketed under the brand names Trosyd and Gyno-Trosyd (Pfizer, laterJohnson & Johnson and nowKenvue). Tioconazole ointments serve to treat women's vaginalyeast infections.[1] They are available in one day doses, as opposed to the 7-day treatments commonly used in the past.
Tioconazole topical (skin) preparations are also available forringworm,jock itch,athlete's foot, andtinea versicolor or "sun fungus".
It was patented in 1975 and approved for medical use in 1982.[2]
Side effects of vaginal tioconazole may include temporaryburning itching, or irritation of thevagina. Vaginal swelling or redness,difficulty or burning during urination,headache,abdominal pain, andupper respiratory tract infection have been reported by people using tioconazole.[3] These side effects may be only temporary, and do not normally interfere with the patient's comfort enough to outweigh the result.[citation needed]
Antimycotic imidazole derivative.
A displacement reaction between 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol and 2-chloro-3-(chloromethyl)thiophene is performed.
