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Timiperone

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From Wikipedia, the free encyclopedia

Typical antipsychotic medication

Pharmaceutical compound

Timiperone
Clinical data

Trade names	Tolopelon
AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 1-(4-fluorophenyl)-4-[4-(2-sulfanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]butan-1-one
CAS Number	57648-21-2^Y
PubChemCID	3033151
ChemSpider	2297930^N
UNII	626DQ7N19L
KEGG	D02035^Y
ChEMBL	ChEMBL2107117
CompTox Dashboard(EPA)	DTXSID9023673
ECHA InfoCard	100.055.328
Chemical and physical data
Formula	C₂₂H₂₄FN₃OS
Molar mass	397.51 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CN(CCC1N2C3=CC=CC=C3NC2=S)CCCC(=O)C4=CC=C(C=C4)F
InChI InChI=1S/C22H24FN3OS/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28)^N Key:YDLQKLWVKKFPII-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Timiperone, sold under the brand nameTolopelon, is atypical antipsychotic of thebutyrophenone class which is marketed inJapan for the treatment ofschizophrenia.^[1]^[2]^[3]^[4] It is similar inchemical structure tobenperidol, but has athiourea group instead of aurea group. It acts as anantagonist for theD₂ and5-HT_2A receptors.^[4]

References

[edit]

^Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1030–.ISBN 978-3-88763-075-1.
^Yamasaki T, Kojima H, Tanaka M, Aibara S, Hirohashi M, Kasai Y, et al. (1981). "Pharmacological studies on timiperone, a new neuroleptic drug Part II: General pharmacological properties".Arzneimittel-Forschung.31 (4):707–15.PMID 6113834.
^Tanaka M, Kojima H, Akashi A (November 1985)."Effect of timiperone, a new antipsychotic drug, on the sleep-wakefulness cycle in cats".Japanese Journal of Pharmacology.39 (3):391–4.doi:10.1254/jjp.39.391.PMID 2869168.
^^a ^bMiyamoto S (2010)."Timiperone". In Stolerman IP (ed.).Encyclopedia of Psychopharmacology. Berlin, Heidelberg: Springer. p. 1323.doi:10.1007/978-3-540-68706-1_1902.ISBN 978-3-540-68706-1. Retrieved2022-03-11.

v t e Antipsychotics (N05A)
Typical	Butyrophenones:Benperidol Bromperidol Bromperidol decanoate Droperidol Haloperidol^# Haloperidol decanoate Moperone Pipamperone Spiperone Timiperone Trifluperidol Diphenylbutylpiperidines:Fluspirilene Penfluridol Pimozide Phenothiazines:Acepromazine Acetophenazine Butaperazine Carphenazine (carfenazine)^‡ Chlorpromazine Cyamemazine Dixyrazine Fluphenazine Fluphenazine decanoate Fluphenazine enanthate Levomepromazine (methotrimeprazine) Mesoridazine Perazine Periciazine Perphenazine BL-1020 Perphenazine decanoate Perphenazine enanthate Piperacetazine Pipotiazine Pipotiazine palmitate Pipotiazine undecylenate Prochlorperazine Promazine Sulforidazine Thiopropazate Thioproperazine Thioridazine Trifluoperazine Triflupromazine Thioxanthenes:Chlorprothixene Clopenthixol Clopenthixol decanoate Flupentixol Flupentixol decanoate Tiotixene (thiothixene) Zuclopenthixol Zuclopenthixol acetate Zuclopenthixol decanoate
Disputed	Benzamides:Amisulpride Levosulpiride Nemonapride Remoxipride^‡ Sulpiride Sultopride Tiapride Veralipride^‡ Butyrophenones:Melperone Tricyclics:Carpipramine Clocapramine Clorotepine Clotiapine Loxapine Mosapramine Oxyprothepin decanoate Others:Molindone
Atypical	Benzisoxazole/benzisothiazoles:Iloperidone Lurasidone Paliperidone Paliperidone palmitate Perospirone Risperidone^# Ziprasidone Butyrophenones:Lumateperone Phenylpiperazines/quinolinones:Aripiprazole Aripiprazole lauroxil Brilaroxazine^† Brexpiprazole Cariprazine Tricyclics:Asenapine Clozapine^# Olanzapine (+samidorphan) Quetiapine Zotepine Others:Blonanserin Pimavanserin Sertindole
Others	Monoamine-depleting agents:Oxypertine Reserpine Tetrabenazine Muscarinic agonists:Xanomeline/trospium chloride Others/unknown:Azacyclonol
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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