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Timelotem

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Timelotem
Clinical data
ATC code
  • none
Identifiers
  • 10-fluoro-3-methyl-7-thiophen-2-yl-2,4,4a,5-tetrahydro-1H-pyrazino[1,2-a][1,4]benzodiazepine
CAS Number
PubChemCID
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC17H18FN3S
Molar mass315.41 g·mol−1
3D model (JSmol)
  • CN1CCN2C(C1)CN=C(C3=C2C=C(C=C3)F)C4=CC=CS4
  • InChI=1S/C17H18FN3S/c1-20-6-7-21-13(11-20)10-19-17(16-3-2-8-22-16)14-5-4-12(18)9-15(14)21/h2-5,8-9,13H,6-7,10-11H2,1H3
  • Key:ICHHTOMWWAMJQP-UHFFFAOYSA-N

Timelotem is abenzodiazepine derivative with an unusual activity profile. Unlike most benzodiazepines, timelotem has little or no activity at theGABAA receptor, but instead acts as an atypicalantipsychotic drug with similar pharmacology and effects to the structurally related drugclozapine.[1] It has two enantiomers, but has only been studied as the racemic mix.

See also

[edit]

References

[edit]
  1. ^Schmidt WJ, Krähling H, Ruhland M (October 1987). "Antagonism of AP-5- and amphetamine-induced behaviour by timelotem as compared with clozapine and haloperidol".Life Sciences.41 (16):1909–14.doi:10.1016/0024-3205(87)90742-9.PMID 2889124.
1,4-Benzodiazepines
1,5-Benzodiazepines
2,3-Benzodiazepines*
Triazolobenzodiazepines
Imidazobenzodiazepines
Oxazolobenzodiazepines
Thienodiazepines
Thienotriazolodiazepines
Thienobenzodiazepines*
Pyridodiazepines
Pyridotriazolodiazepines
Pyrazolodiazepines
Pyrrolodiazepines
Tetrahydroisoquinobenzodiazepines
Pyrrolobenzodiazepines*
Benzodiazepine prodrugs
* atypical activity profile (notGABAA receptor ligands)
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