 | |
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | IV,IM,SC, Other |
| ATC code |
|
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Metabolism | Liver |
| Excretion | Kidneys |
| Identifiers | |
| |
| CAS Number |
|
| PubChemCID | |
| ChemSpider |
|
| UNII |
|
| KEGG |
|
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.034.559 |
| Chemical and physical data | |
| Formula | C12H17NOS |
| Molar mass | 223.33 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
 N Y (what is this?) (verify) | |
Tiletamine is adissociative anesthetic andpharmacologically classified as anNMDA receptor antagonist.[1] It is related chemically toketamine.[2] Tiletamine hydrochloride exists as odorless white crystals.
It is used inveterinary medicine in thecombination productTelazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use incats anddogs.[3][4][5] It is sometimes used in combination withxylazine (Rompun) to chemically immobilize largemammals such aspolar bears[6] andwood bison.[7] Telazol is the only commercially available tiletamine product in theUnited States. It is contraindicated in patients of anASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy,glaucoma, or penetrating eye injuries.[3]
Recreational use of telazol has been documented.[8] Animal studies have also shown that tiletamine produces rewarding and reinforcing effects.[9] Products that combine Tiletamine andZolazepam are classified asSchedule IIIcontrolled substances in the United States.[10] Otherwise, as noted by theDEA, tiletamine is unscheduled: “…[R]ules applicable to the scheduling of tiletamine and zolazepam as individual entities are not warranted [or in effect] at this time. Neither tiletamine nor zolazepam, as discrete substances, is perceived to pose a significant threat to the health and general welfare at this time…”[11]