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Thyrotropin-releasing hormone receptor

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

TRHR

Identifiers

Aliases

TRHR, TRH-R, thyrotropin releasing hormone receptor, CHNG7

External IDs

OMIM:188545;MGI:98824;HomoloGene:20707;GeneCards:TRHR;OMA:TRHR - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8q23.1	Start	109,086,585bp^[1]
Band	8q23.1	End	109,121,565bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15 B3.2\|15 16.82 cM	Start	44,059,531bp^[2]
Band	15 B3.2\|15 16.82 cM	End	44,099,308bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

Achilles tendon

gonad

pituitary gland

anterior pituitary

ventricle of the heart

atrium

right auricle of heart

left ventricle

hippocampal formation

Top expressed in

facial motor nucleus

lumbar subsegment of spinal cord

anterior amygdaloid area

anterior horn of spinal cord

motor neuron

ventral tegmental area

urethra

nucleus accumbens

dentate gyrus of hippocampal formation granule cell

subiculum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G protein-coupled receptor activity signal transducer activity thyrotropin-releasing hormone receptor activity
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane
Biological process	signal transduction G protein-coupled receptor signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


7201


22045

Ensembl


ENSG00000174417


ENSMUSG00000038760

UniProt


P34981


P21761

RefSeq (mRNA)


NM_003301


NM_013696

RefSeq (protein)


NP_003292


NP_038724

Location (UCSC)

Chr 8: 109.09 – 109.12 Mb

Chr 15: 44.06 – 44.1 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Thyrotropin-releasing hormone receptor (TRHR) is aG protein-coupled receptor which bindsthyrotropin-releasing hormone.^[5]^[6]

The TRHR is found on the cell membrane ofthyrotropes of theanterior pituitary. When the TRHR is activated it associates with aG_αq/11 protein. The TRHR-G protein complex then activates phospholipase C, which causes the formation ofinositol triphosphate (IP3) anddiacylglycerol (DAG). This leads to an increase in cytoplasmic calcium ion concentrations which stimulates the exocytosis ofthyroid-stimulating hormone (TSH) into the blood.

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000174417 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000038760 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yamada M, Monden T, Konaka S, Mori M (November 1993). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8".Somatic Cell and Molecular Genetics.19 (6):577–80.doi:10.1007/BF01233384.PMID 8128317.S2CID 44982871.
^Gershengorn MC (1993). "Thyrotropin-releasing hormone receptor: Cloning and regulation of its expression". Vol. 48. pp. 341–63.doi:10.1016/B978-0-12-571148-7.50016-6.ISBN 9780125711487.PMID 8382829.{{cite book}}:|journal= ignored (help);Missing or empty|title= (help)

External links

[edit]

"Thyrotropin-Releasing Hormone Receptors".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2012-09-08. Retrieved2007-10-25.
Receptors,+Thyrotropin-Releasing+Hormone at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

Neuropeptide receptors

G protein-coupled receptor

Hormone receptors

Hypothalamic	CRH FSH LHRH TRH Somatostatin
Pituitary	Vasopressin 1A 1B 2 Oxytocin LHCG TSH
Other	Atrial natriuretic factor NPR3 Calcitonin Cholecystokinin A B VIP