Thymidylate synthase inhibitors are chemical agents whichinhibit the enzymethymidylate synthase and have potential as an anticancerchemotherapy.[1] This inhibition prevents themethylation of C5 of deoxyuridine monophosphate (dUMP) thereby inhibiting the synthesis ofdeoxythymidine monophosphate (dTMP). The downstream effect is promotion of cell death because cells would not be able to properly undergo DNA synthesis if they are lacking dTMP, a necessary precursor to dTTP.[2]Five agents were in clinical trials in 2002:raltitrexed,pemetrexed,nolatrexed,Plevitrexed(ZD9331/BGC9331), andGS7904L.[3]
Examples include
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