Thethiopurine drugs arepurineantimetabolites widely used in the treatment ofacute lymphoblastic leukemia,autoimmune disorders (e.g.,Crohn's disease,rheumatoid arthritis), andorgan transplant recipients.
Metabolism is catalyzed byS-methyltransferase andnudix hydrolase 15 (NUDT15).[1]
Litigation over patents covering diagnostic kits to monitor the dosing of these drugs led to a US Supreme Court case,Mayo Collaborative Services v. Prometheus Laboratories, Inc. that dramatically changed the nature of patent law in the United States.[2][3]
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