Thiamphenicol (also known asthiophenicol anddextrosulphenidol) is anantibiotic.[1] It is themethyl-sulfonyl analogue ofchloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble inlipids. It is used in many countries as aveterinary antibiotic, but is available in China, Taiwan, Brazil, Morocco, and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated withaplastic anaemia.[2]
Unlike chloramphenicol, thiamphenicol is not readily metabolized in cattle, poultry, sheep, or humans, but is predominantly excreted unchanged. In pigs and rats the drug is excreted both as parent drug and as thiamphenicol glucuronate.[2]
^Fisch A, Bryskier A (2005). "Chapter 33 : Phenicols". In Bryskier A (ed.).Antimicrobial Agents. American Society for Microbiology.doi:10.1128/9781555815929.ch33.
^abFrancis PG (1997)."Thiamphenicol".Residues of some veterinary drugs in animals and foods. FAO Food and Nutrition Paper (41/9). Rome: Food and Agriculture Organization (FAO), World Health Organization (WHO).ISBN92-5-103972-0.
^Fuchs FD (2004)."Tetraciclinas e cloranfenicol". In Fuchs FD, Wannmacher L, Ferreira MB (eds.).Farmacologia clínica: fundamentos da terapêutica racional (in Portuguese) (3rd ed.). Rio de Janeiro: Guanabara Koogan. pp. 375.ISBN0-7216-5944-6.
^Serra A, Schito GC, Nicoletti G, Fadda G (2007). "A therapeutic approach in the treatment of infections of the upper airways: thiamphenicol glycinate acetylcysteinate in sequential treatment (systemic-inhalatory route)".International Journal of Immunopathology and Pharmacology.20 (3):607–617.doi:10.1177/039463200702000319.PMID17880774.
Marchese A, Debbia EA, Tonoli E, Gualco L, Schito AM (December 2002). "In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy".Journal of Chemotherapy.14 (6):554–561.doi:10.1179/joc.2002.14.6.554.PMID12583545.S2CID22843552.
Raymond J, Boutros N, Bergeret M (2004). "[Role of thiamphenicol in the treatment of community-acquired lung infections]".Médecine Tropicale.64 (1):33–38.PMID15224555.
N
Y (what is this?) (verify)