Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

Tetrazolylglycine

From Wikipedia, the free encyclopedia
Tetrazolylglycine
Chemical structure of tetrazolylglycine
Chemical structure of tetrazolylglycine
Names
IUPAC name
(RS)-Amino(1H-tetrazol-5-yl)acetic acid
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
  • InChI=1S/C3H5N5O2/c4-1(3(9)10)2-5-7-8-6-2/h1H,4H2,(H,9,10)(H,5,6,7,8) checkY
    Key: UKBRUIZWQZHXFL-UHFFFAOYSA-N checkY
  • InChI=1/C3H5N5O2/c4-1(3(9)10)2-5-7-8-6-2/h1H,4H2,(H,9,10)(H,5,6,7,8)
    Key: UKBRUIZWQZHXFL-UHFFFAOYAB
  • O=C(O)C(N)c1[nH]nnn1
Properties
C3H5N5O2
Molar mass143.106 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Chemical compound

Tetrazolylglycine (Tet-Gly,LY-285,265) is a potent and selectiveNMDA receptoragonist, stimulating the NMDA receptor with higher potency than eitherglutamate orNMDA.[1] It is a potentconvulsant andexcitotoxin and is used in scientific research.[2][3]

References

[edit]
  1. ^Lunn WH, Schoepp DD, Calligaro DO, Vasileff RT, Heinz LJ, Salhoff CR, O'Malley PJ (1992). "DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy".Journal of Medicinal Chemistry.35 (24):4608–12.doi:10.1021/jm00102a015.PMID 1361579.
  2. ^Schoepp DD, Smith CL, Lodge D, Millar JD, Leander JD, Sacaan AI, Lunn WH (1991). "D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist".European Journal of Pharmacology.203 (2):237–43.doi:10.1016/0014-2999(91)90719-7.PMID 1686860.
  3. ^Schoepp DD, Lunn WH, Salhoff CR, McDonald JW (1994). "The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin".European Journal of Pharmacology.270 (1):67–72.doi:10.1016/0926-6917(94)90081-7.PMID 8157082.
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
GABA receptor antagonists
GABA synthesis inhibitors
Glycine receptor antagonists
Glutamate receptor agonists
Convulsantbarbiturates
Other
Stub icon

Thisdrug article relating to thenervous system is astub. You can help Wikipedia byadding missing information.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Tetrazolylglycine&oldid=1329038148"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2026 Movatter.jp