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| Clinical data | |
|---|---|
| Other names | THDOC |
| Identifiers | |
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| CAS Number |
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| PubChemCID | |
| UNII | |
| ECHA InfoCard | 100.008.457 |
| Chemical and physical data | |
| Formula | C21H34O3 |
| Molar mass | 334.500 g·mol−1 |
| 3D model (JSmol) | |
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| (verify) | |
Tetrahydrodeoxycorticosterone (abbreviated asTHDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to asallotetrahydrocorticosterone, is anendogenousneurosteroid.[1] It is synthesized from the adrenal hormonedeoxycorticosterone by the action of two enzymes,5α-reductase type I and3α-hydroxysteroid dehydrogenase.[2] THDOC is a potentpositive allosteric modulator of theGABAA receptor, and hassedative,anxiolytic andanticonvulsant effects.[3][4][5] Changes in the normal levels of this steroid particularly duringpregnancy andmenstruation may be involved in some types ofepilepsy (catamenial epilepsy) andpremenstrual syndrome,[6] as well asstress,anxiety anddepression.[7][8][9][10][11]
