Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Terodiline

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Terodiline
Clinical data
ATC code
Identifiers
  • N-tert-butyl-4,4-di(phenyl)butan-2-amine
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC20H27N
Molar mass281.443 g·mol−1
3D model (JSmol)
  • c1ccccc1C(c2ccccc2)CC(NC(C)(C)C)C
  • InChI=1S/C20H27N/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,16,19,21H,15H2,1-4H3 checkY
  • Key:UISARWKNNNHPGI-UHFFFAOYSA-N checkY
  (verify)

Terodiline is a drug used inurology as anantispasmodic.

It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity.

However, it also blocksKv11.1 ion channels and consequently can pose a risk fortorsades de pointes. This cardiotoxicity is concentration dependent.[1]

References

[edit]
  1. ^Thomas SH, Higham PD, Hartigan-Go K, Kamali F, Wood P, Campbell RW, Ford GA (1995)."Concentration dependent cardiotoxicity of terodiline in patients treated for urinary incontinence".Br Heart J.74 (1):53–6.doi:10.1136/hrt.74.1.53.PMC 483946.PMID 7662454.
Urologicals, including antispasmodics (G04B)
Acidifiers
Urinaryantispasmodics
(primarilyantimuscarinics)
Other urologicals
Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
KCaTooltip Calcium-activated potassium channel
Blockers
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
Activators
Sodium
VGSCsTooltip Voltage-gated sodium channels
Blockers
Activators
ENaCTooltip Epithelial sodium channel
Blockers
Activators
ASICsTooltip Acid-sensing ion channel
Blockers
Chloride
CaCCsTooltip Calcium-activated chloride channel
Blockers
Activators
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Blockers
Activators
Unsorted
Blockers
Others
TRPsTooltip Transient receptor potential channels
LGICsTooltip Ligand gated ion channels
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(andprodrugs)


Stub icon

Thisdrug article relating to thegenito-urinary system is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Terodiline&oldid=1309203383"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp